摘要
为研究血清组织多肽特异性抗原 (TPS)水平在肝癌病情监测和预后判断中的价值 ,对 96例肝癌手术病人和 2 2例肝癌接受聚能刀 (RF)治疗的病人进行 6～ 12个月的TPS监测。接受RF治疗的病人根据疗效分为好转、稳定、恶化 3组 ,在各个时期 ,恶化组的TPS水平都显著高于好转组 (P <0 0 1)。肝癌手术病人随访 1年 ,TPS表现出预告复发和转移的作用 ,提前时间为 3～ 6个月。无论是在手术还是接受RF治疗的病人 ,死亡者的血清TPS水平都显著高于生存者 (P <0 0 1)。
To investigate the prognostic value of serum levels of tissue polypeptide specific antigen (TPS) in patients with hepatocellular carcinoma(HCC). Ninety six patients who had undergone hepatoma resections and 22 patients who received radio frequency ablations (RF) were followed up for 6～12 months.The serum levels of TPS were repeatedly determined.The RF group patients were divided into three subgroups: improved ,stable,and advanced.The median levels (U/L) of serum TPS in advanced subgroup were always higher than those in improved subgroup ( P <0 01, Wilcoxon test). High levels of serum TPS predicted early a recurrence and metastasis of the hepatoma by 3 to 6 months.The median TPS levels of the non survivors were higher than the survivors,and the difference was significant statistically ( P <0 01,Wilcoxon test).The results suggested that TPS could be a useful prognostic indicator of HCC after treatment.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2001年第11期792-794,共3页
Medical Journal of Chinese People's Liberation Army
基金
国际科技合作课题 (瑞典康乃格生物工程研究所资助
编号98C0 1)
关键词
肝细胞癌
组织多肽特异性抗原
预后
射频治疗
TPS
tissue polypeptide specific antigen
hepatocellular carcinoma
prognosis
radio frequency ablation
