摘要
［目的］探讨卡铂加氟尿嘧啶脱氧核苷配合放射治疗中晚期食管癌的疗效。［方法］２３２例中晚期食管癌随机分为卡铂＋氟尿嘧啶脱氧核苷配合放疗的放化组与单放组。放射治疗采用 ６０ COγ射线常规照射，D T ６０Gy～７０Gy；化疗在放射治疗的第１、４周内进行。两组病例均随访５年。［结果］放化组与单放组１、３、５年生存率分别为７３．３％、３２．８％、１９．８％和５５．２％、１７．２％、７．８％。放化组１、３、５年生存率明显高于单放组（P＜０．０１），且无严重毒副反应。２个组局部未控或复发率差异无显著意义（P＞０．０５），但远处转移率放化组明显低于单放组（P＜０．０５）。［结论］卡铂加氟尿嘧啶脱氧核苷配合放射治疗中晚期食管癌可提高远期生存率与近期疗效。
To study the therapeutic effect of chemotherapy with carboplatin and floxuridine combined with radiotherapy for advanced esophageal carcinoma.Two hundred and thirty-two patients with advanced esophageal carcinoma were randomized into radiotherapy plus chemotherapy group(C+R,116patients)and radiotherapy alone group(R,116patients). 60 Coγ-ray was used for all patients with a total dose of60Gy～70Gy.Chemotherapy(carboplatin plus floxuridine)was given in the first and4th week of radiotherapy in R+C group.Both groups were followed for five years.The1-,3-and5-year survival rates were73.3%,32.8%,19.8%in R+C group and55.2%,17.2%,7.8%in R group,respectively.The survival rate in R+C group were higher than that in R group(P<0.01),without serious side effect in R+C group.There had no diffierence in uncontrol or relapse rate between two groups(P>0.05),distant metastasis rate in R+C group was much lower than that in R group(P<0.05).[Conclusion]Chemotherapy with carboplatin and floxuridine combined with radiotherapy for advanced esophageal carcinoma could improve long term survival rate and short term response of patients.
出处
《肿瘤学杂志》
CAS
2003年第3期158-160,共3页
Journal of Chinese Oncology
