摘要
目的:探讨小剂量顺铂同步放化疗对中晚期食道癌的放疗增敏作用。方法:将70例不宜手术的中晚期食道癌患者随机分为顺铂增敏放疗组35例和单纯放疗组35例,两组放射治疗方法相同,均采用常规设野,常规分割外照射,放疗增敏组在每日放疗的同时,采用小剂量顺铂静滴。结果:全组病例随访3年以上,放疗增敏组与对照组完全缓解率(CR)分别为(21/35)60%和(11/35)31.4%(P<0.05),两组1、2、3年生存率分别为71.4%、22.7%、10.6%和42.9%、8.6%、2.8%(P<0.05),放疗增敏组毒副反应可耐受。结论:小剂量顺铂作为增敏剂联合放疗治疗中晚期食道癌具有较好的疗效和较低的毒副反应。
Objective： To evaluate the radiosensitizing effect of low-dose cisplatin in treating advanced esophageal carcinoma. Methods： The data of 70 patients with unresectable intermediate and advanced esophageal carcinoma, from April 2000 to November 2002, were randomized into the radiosensitization group with 35 patients （RS group） or the simple-radiotherapy group with 35 patients （RT group）. The patients in the RS group were treated with radiotherapy combined with low-dose cisplatin, while those in the RT group received radiotherapy alone. Results： All patients were followed up for more than 3 years. The rate of complete remission was 60% in the RS group and was 31.4% in the RT group （P〈0.05）. The 1-, 2- and 3-year survival rate was 71.4%, 22.7% and 10.6% in the RS group and 42.9%, 8.6% and 2.8% in the RT group, respectively （P〈0.05）. Toxic effects were more severe in the RS group than in the RT group, however, it was tolerable for all of the patients. Conclusion： Lowdose cisplatin combined with radiotherapy can effectively treat advanced esophageal carcinoma with fewer side effects .
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2006年第13期768-770,共3页
Chinese Journal of Clinical Oncology
关键词
中晚期食管癌
放射疗法
化学疗法
Intermediate and advanced esophageal carcinoma Radiotherapy Chemotherapy
