摘要
目的目前主要用于治疗阿尔茨海默病(Alzheimerdisease,AD)的乙酰胆碱酯酶抑制剂价格昂贵,难以普及应用,为进一步寻求费用合理、药效确切的AD的治疗药物,观察尼尔雌醇(雌激素替代疗法)并石杉碱甲治疗AD改善认知功能的有效性及安全性。方法把60例女性AD患者随机分为两组,每组30例,联合治疗组采用石杉碱甲片200μg/d分2次口服和尼尔雌醇片2mg,1次/2周,对照组服用石杉碱甲片200μg/d分2次口服,疗程均为24周;两组患者的病情治疗前、治疗后8,24周均采用简易精神状态检查(MMSE)、临床痴呆程度量表(CDR)、日常生活活动能力(ADL)评分。结果治疗8周后,治疗组与对照组的MMSE、ADL评分(分别为19.2±2.5与16.9±2.1、45.9±7.1与48.3±6.1)差异有显著性意义(t=2.140,t=2.616,P均<0.05)。治疗24周后,治疗组与对照组的MMSE、CDR、ADL评分(23.1±2.3与19.3±2.1,1.1±0.2与1.4±0.3,40.1±7.2与43.1±6.1)差异有显著意义(t=3.076、t=2.216、t=3.662,P依次<0.01、0.05、0.01)。体检及实验室检查无明显的乳腺、子宫及肝肾功能异常。结论雌激素配合石杉碱甲能有效地治疗女性轻、中度AD患者,对患者的认知功能和日常生活自理能力均有改善,耐受性好,安全性高。
Aim To investigate the efficacy and safe ty of nilestriol combined with huperzine A in improvi ng cognition of female patients with Alzheimer' s disease(AD).Methods Sixty female patients with AD,aged60-75(68±5),were randomly divided into 2groups of 30patients:combined treatment group(treated with nilestriol 2mg once eve ry fortnight and huperzine A 100μg bid for 24weeks),and control group(trerted with huperzine A 100μg bid for 24weeks).Mini-mental state examination(MMSE),examination of activity of daily life(ADL),and clinical dementia rating(CDR)were conducted before and 8and 24weeks after the treatment.Results The MMSE scores were 15.5±2.5and 15.8±2.4in the com-bined treatment group and control group respectively(P>0.05),19.2±2.5and 16.9±2.1in the 2groups 8week s after respectively(t=2.140,P<0.05),and 23.1±2.3and 19.3±2.124weeks a fter respectively(t=3.076,P<0.01).The CDR scores were 2.2±0.3and 2.1±0.2before treatment in the 2groups resp ectively(P>0.05),1.9±0.2and2.0±0.38weeks after in the 2groups r espectively(P>0.05),and1.1±0.2and 1.4±0.324weeks after in the 2groups respectively(t=2.216,P<0.01).The ADL scores were 49.2±6.1and 49.4±7.1in the 2groups respectively before tre atment (P>0.05);45.9±7.1and48.3±7.98weeks after in the 2groups respectively(t=2.616,P<0.05),and 40.9±7.2and 43.1±6.124weeks a fter in the 2groups re-spectively(t=3.662,P<0.01).Physical and laboratory examinations showed no obvious abnormalities in b reast,uterus,and liver and renal functions.Conclusion Improving the cognition and ability of daily life and with good tolerance and high reliabi lity,nilestriol combined with huperzine Ais effective in treating mild and mod erate AD patients.
出处
《中国临床康复》
CAS
CSCD
2003年第10期1538-1539,共2页
Chinese Journal of Clinical Rehabilitation
