摘要
目的:研究石杉碱甲对遗忘型轻度认知损伤(mildcognitiveimpairment,MCI)患者内隐和外显记忆功能的影响,为MCI患者的记忆功能康复训练提供理论依据。方法:共入选20例遗忘型MCI患者,为2002-01/2003-01解放军总医院南楼神经科收治患者,随机分为治疗组和非治疗组各10例。两组均维持既往基础用药,治疗组10例在此基础上每日口服石杉碱甲0.2mg,连续12周,用药前后均行外显和内隐记忆功能评定。结果:遗忘型MCI患者存在语义性启动效应和知觉性启动效应,用药后治疗组的自由回忆正确率变化幅度(0.07±0.04)较非治疗组(0.01±0.05)大,差异有显著性意义(P<0.05),再认正确率的变化幅度(0.08±0.06)较非治疗组(0.03±0.04)大,差异有显著性意义(P<0.05),而语义启动效应、知觉启动效应的变化幅度则差异没有显著性意义(P>0.05)。结论:石杉碱甲对遗忘型MCI患者外显和内隐记忆具有不同影响,提示多重记忆系统的存在,同时也为MCI患者的记忆康复治疗提供理论依据。
AIM:To study the effect of huperzine A on the function of implicit memory and explicit memory in patients with amnesia mild cognitive impairment(MCI),and provide theoretic evidence for rehabilitation training of mental function in patients with MCI. METHODS:The prospective control method was used. Twenty patients with amnesia mild cognitive impairment were selected into this research,which were treated in the Department of Neurology,South Building,General Hospital of Chinese PLA,between January 2002 and January 2003.They were randomly divided into treated group and control group.Ten patients in treated group were taken 0.2 mg of huperzine A orally for successive 12 weeks and another 10 patients were in the control group.All patients in the two groups remained usual basic medicine taken.The function of implicit memory and explicit memory were evaluated before and after drug taken. RESULTS:The switching on effects of semantic and perception were found in patients with amnesia mild cognitive impairment.After drug taken, the treated group showed significant difference(P< 0.05) in change range of correct rate of free recall(0.07±0.04)as compared with the control group(0.01±0.05).Significant difference(P< 0.05) was also found in change range of correct rate of re cognition rate between the treated group(0.08±0.06) and the control group(0.03±0.04).Whereas there was no significant difference in change range of switching on effects of semantic and perception in the two groups(P >0.05). CONCLUSION:Different effects of huperzine A on implicit memory and explicit memory in patients with amnesia mild cognitive impairment are found,and the resuts suggest the existence of multiple memory systems.This study provides theoretical evidence for memory rehabilitation of the patients with amnesia mild cognitive impairment.
出处
《中国临床康复》
CSCD
北大核心
2005年第8期23-25,共3页
Chinese Journal of Clinical Rehabilitation
