摘要
目的探讨阿尔茨海默病(AD)患者脑脊液Tau蛋白含量变化的临床意义。方法采用夹心酶联免疫吸附法(ELISA)测定了18例AD、16例多发性梗死性痴呆(MID)、19例其他神经系统疾病患者脑脊液中Tau蛋白含量。结果脑脊液中Tau蛋白含量,3组间差异有非常显著意义(P<0.01);AD组与MID组间及AD组与对照组间差异均有非常显著意义(分别为P<0.01和P<0.01);MID组和对照组间差异无显著意义(P>0.05)。AD组患者脑脊液中Tau蛋白含量随年龄有增高趋势,但统计学检验与年龄无相关关系(P>0.05)。轻、中、重度痴呆患者间的差异无显著性(P>0.05)。结论脑脊液Tau蛋白的升高有助于AD的诊断和鉴别诊断。
Objective To investigate the diagnostic value of cerebrospinal fluid(CSF) level of tau protein in patients with Alzheimer's disease(AD).Methods The CSF level of tau protein in 18 patients with AD,16 patients with multiple infarct dementia(MID) and 17 patients with other neurological disease was measured by ELISA.Results The CSF level of tau protein was a significant difference between AD group and MID group(P< 0.01),between AD group and controls(P< 0.01),but there was not a significant difference between MID group and controls(P >0.05).Accompanied by aged,the CSF level of tau protein in AD group elevated,but it did not show a correlation.There was not a significant difference in varying degree patients(P >0.05).Conclusion The CSF level of tau protein is helpful in the diagnosis and distinction of AD.
出处
《中国临床康复》
CSCD
2002年第13期1909-1910,共2页
Chinese Journal of Clinical Rehabilitation
