摘要
的观察晚期癌症患者炎性反应递质释放,探讨自控硬膜外镇痛(PECA)缓解炎性反应递质释放引起的躯体病和内脏痛。方法62例胸、腹腔恶性肿瘤未能手术切除,亦未进行放疗和化疗的晚期癌症患者。随机分为两组,PCEA组(32例)和非PCEA组(30例)。分别与PCEA前、PCEA后3～7d抽血检测中性粒细胞粘附分子CD11b的平均荧光强度(MFI),白介素-6(IL-6)和肿瘤坏死因子(TNF-α)。结果:PCEA组较非PCEA组第7天炎性反应递质水平明显降低(t=3.198,P<0.01)。PCEA组内炎性递质水平第7天比PCEA前降低(F=8.198,P<0.01)。结论PCEA可减少晚期癌症患者的炎性反应递质释放。
Aim To study the effect of patient-contr olled epidural anal-gesia(PCEA)on release of cytokines in patient su ffering late cancer.Methods 62patient suffering late malignant tumor in thoracic-abdominal cavity(non operation,radiotherapy and chemiotherapy were practiced)were randomly divided into two groups:PC EA group(n=32)and non-PCEA group(n=30).The blood specimens were drawn to te st the mean fluores-cent intensity of adhesion molecule-CD11b in neutrophils and the lever o f interleukin-6and tumor necrosis fa ctor-αat before PCEA,3and 7d after PCEA.Results Compared with non-PCEA group,the le ver of cytokines in PCEA group were obvious decreased(P<0.01).In PCEA group,the lever of cytokines at the 7th day afte r PCEA were remarkably reduced than the base before PCEA(P<0.01).Conclusion PCEA can reduce the re-lease of cytokines in patients suffe ring late cancer.
出处
《中国临床康复》
CSCD
2003年第8期1280-1281,共2页
Chinese Journal of Clinical Rehabilitation
