摘要
Raf kinase inhibitor protein (RKIP) was originally identified as a protein that bound membrane phospholipids and was named
Rafkinase inhibitor protein （RKIP） was originally identified as a protein that bound membrane phospholipids and was named phosphatidylethanolamine binding protein-2 （PEBP-2）. RKIP was than identified as a protein that bound Raf and blocked its ability to phosphorylate MEK, thus earning its new name of RKIP. Subsequent to identification of its role in the Raf： MEK pathwa）, RKIP has been demonstrated to regulate several other signaling pathways including G-protein signaling and NF KB signaling. Rs involvement in several signaling pathways has engendered RKIP to contribute to several physiological processes including membrane biosynthesis, spermatogenesis, neural development and apoptosis. RKIP is expressed in many tissues including brain, lung, and liver and thus, dysregulation of RKIP expression or function has potential to contribute to pathophysiologyin these tissues.
出处
《中国肺癌杂志》
CAS
2009年第6期I0006-I0006,共1页
Chinese Journal of Lung Cancer
