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超声激活血卟啉杀伤癌细胞的扫描电镜观察 被引量：2

The scanning electron microscope observation of two kinds cancer cells treated by ultrasound irritating HpD
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摘要 利用频率为2MHz,强度为0.9W/cm2的超声(Ultrasound,US)激活血卟啉(Hematoporphyrinderivatives,HpD)对在体的腹水型艾氏腹水瘤细胞(EhrlichAscitesTumor,EAT)和S180(Sarcoma180,S180)细胞进行抑癌作用研究。通过扫描电子显微镜观察处理后细胞形态的变化,结果表明:超声激活血卟啉对艾氏腹水瘤细胞和S180细胞均有明显的杀伤效果,且通过对损伤不同形态的比较,得出S180细胞膜较艾氏腹水瘤细胞膜对于声动力疗法(SonodynamicTherapy,SDT)更为敏感。 The antitumor effects of hematoporphyrin derivative (HpD)activated by ultrasound (US)was studied on Sarcoma180(S180)and Ehrlich ascites tumor(EAT)cells through scanning electronic microscope.The results indicated that the synergia of US and HpD had remarkable antitumor effects on ascitic S180 and EAT cells.At the same time,the comparison between two ascitic tumor cells′ images of injured membranae illustrated the S180 cells was more sensitive than EAT cells to HpD activated by US.
作者 李萌 刘全宏 齐浩 张金选 张坤 王攀
机构地区 陕西师范大学生命科学学院
出处 《西北大学学报（自然科学版）》 CAS CSCD 北大核心 2003年第2期223-225,共3页 Journal of Northwest University（Natural Science Edition）
基金 国家自然科学基金资助项目(39870240) 教育部"高等学校骨干教师资助计划"项目(2000)
关键词 癌细胞 血卟啉 抑癌作用 超声 声动力疗法 艾氏腹水瘤 细胞形态 扫描电镜观察 ultrasound (US) hematoporphyrin derivative(HpD) Ehrlich ascites tumor(EAT)
分类号 R735.5 [医药卫生—肿瘤] R454.3 [医药卫生—治疗学]
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参考文献10

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  • 2孙世惠,刘全宏,齐浩,张军平,任耀辉,丁德成.低强度超声激活血卟啉对S180细胞的杀伤作用[J].西北大学学报（自然科学版）,2002,32(2):211-213. 被引量：5
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二级参考文献5

共引文献22

同被引文献25

  • 1高炳华,王新生,孙黎,薄爱华.温热处理对K562细胞系表达热休克蛋白gp96的影响[J].河北医科大学学报,2009,30(9):869-871. 被引量：2
  • 2刘全宏,王仲会,任耀辉,袁仕取,王智明,路小龙,张勤.超声激活血卟啉杀伤S180癌细胞研究初报[J].科学通报,1994,39(10):936-939. 被引量：15
  • 3UMEMURA S, YUMITA N, NISHIFAKI R, et al. Sonochemical activation of hematoporphyrin: A potential modality for cancer treatment[ J]. IEEE Ultrasonics Symosium, 1989,9:955-960.
  • 4UMEMURA S, YUMITA N, NISHIFAKI R, et al. Mechanism of cell damage by ultrasound in combination with hematoporphyrin[J]. Jpn J Cancer Res, 1990,81(9): 962- 966.
  • 5QUAN HONG LIU, XIAO BING WANG, PAN WANG, et al. Sonodynamic effects of protoporphyrin Ⅸ disodium salt on isolated sarcoma 180 cells [ J ]. Ultrasonics, 2006, 45(1-4) :56- 60.
  • 6WORTHINGTON AE, THOMPSON J, Rauth AM, et al.Mechanism of ultrasound enhanced porphyrin cytotoxicity. Part Ⅰ: A search for free radical effect[J]. Ultrasound in Medicine & Biology,1997,23 (7) : 1 095-1 097.
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  • 9LIU Quan-hong, SUN Shi-hui, XIAO Ya-ping, et al. Synergistic anti-tumor effect of ultrasound and hematoporphyrin on sarcoma180 cells with special reference to the changes of morphology and cytochrome oxidase activity of tumor cells [ J ]. J Exp Clin Cancer Res, 2004,23 ( 2 ) : 333-341.
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西北大学学报（自然科学版）
2003年 第2期

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