摘要
首先介绍了超声作用的物理机理和血卟啉及其衍生物的化学结构及物理化学性质,对超声激活血卟啉抗肿瘤疗法(声动力学疗法)近15年国内外的试验进展情况进行了总结,对比了不同参数超声系统对不同细胞系肿瘤的作用效果。重点探讨了超声激活血卟啉抑制肿瘤增殖的物理、化学和生物学机理,着重介绍了单线态氧机制和自由基理论,并对今后的基础研究和临床实践进行了展望。
Physical mechanism of ultrasound, chemical structure, and physical and chemical properties of Hematoporphyrin and its ramifications are introduced. Experimental advances of sonodynamic therapy （SDT） for tumor-inhibition during the past 15 years are summarized, and the effects of ultrasounds with different parameters on various tumor ceils presented. Basic physical, chemical and biological mechanisms of SDT that is effective in suppressing tumor-proliferation, and two popular fundamental theorems, i.e., radical theorem and mongline-state oxidation theorem, are discussed. Finally the prospect of this field is outlined.
出处
《声学技术》
EI
CSCD
北大核心
2005年第4期223-226,232,共5页
Technical Acoustics
基金
国家自然科学基金资助项目(20272035)
教育部科学技术研究重点项目(104167)
