摘要
目的研究血管紧张素转化酶（ＡＣＥ）基因的插入／缺失（Ｉ／Ｄ）多态性与原发性高血压的关系。方法应用ＰＣＲ的方法分别检测７２例原发性高血压患者和９３例正常血压组的ＡＣＥ基因第１６内含子的Ｉ／Ｄ多态性。结果共得到３种基因型：纯合缺失型（ＤＤ），纯合插入型（Ｉ），杂合型（ＩＤ）。原发性高血压患者Ｄ等位基因的频率（０．６２）高于健康对照组（０．４８）（Ｐ＜０．０５）。结论ＡＣＥ基因的Ｉ／Ｄ多态性可能与原发性高血压有关。
Aim\ This study was to investigate the potential association of the angiotensin converting enzyme(ACE) insertion/deletion(I/D) polymorphism with hypertension in Chinese.\ Methods\ A 287 bp I/D polymorphism in intron 16 of the ACE gene was examined by polymerase chain reaction in a cross sectional study of 93 healthy subjects and 72 patients with essential hypertension.\ All subjects were from the same geographic region.\ Results\ Polymorphism was characterized by three genotypes:homozygous alleles DD,II, and heterozygous alleles ID.\ The frequency of deletion alleles was higher(0 62) in the hypertension group than in healthy subjects(0 48) (P<0 025).\ Conclusion\ This finding comfirms that a deletion polymorphism of ACE gene is associated with hypertension in Chinese.
出处
《高血压杂志》
CSCD
1997年第3期194-196,共3页
Chinese Journal of Hypertension
关键词
基因多态性
原发笥
高血压
ACE
angiotensin converting enzyme
\ gene polymorphism
\ essential hypertension
