摘要
目的 探讨乳腺癌中survivin蛋白的表达及其与肿瘤细胞增殖和腋窝淋巴结转移的关系。方法 收集乳腺癌 74例 ,其中有腋窝淋巴结转移的 3 4例 ,用免疫组化染色检测survivin和增殖细胞核抗原 (Proliferatingcellnuclearantigen ,PCNA)蛋白的表达情况。结果 ①乳腺癌组织中有survivin蛋白的表达 ,其阳性表达率为 64 .9%。②survivin蛋白表达阳性的乳腺癌细胞PCNA的标记指数明显高于survivin蛋白表达阴性者。③无腋窝淋巴结转移的乳腺癌中survivin蛋白阳性表达率明显低于有腋窝淋巴结转移者。结论 乳腺癌组织中有survivin蛋白的表达 ,且其表达与肿瘤细胞增殖和腋窝淋巴结转移有关。
Objective To investigate the expression of survivin and its correlation with tumor cell proliferation and axillary lymph node metastasis in breast cancer. Methods Expressions of survivin and proliferating cell nuclear antigen(PCNA) in 74 cases of breast cancer(34 cases with axillary lymph node metastasis) were measured by immunohistochemistry. Results (1) There was expression of survivin in 64.9% of breast cancer. (2) Labeling idex(LI) of PCNA in breast cancer cells with positive expression of survivin was significantly higher than that with negative survivin. (3) The positive percent of survivin expression in breast cancer with axillary lymph node metastasis was higher than that without axillary lymph node metastasis. Conclusion The expression of survivin in breast cancer is related to PCNA and axillary lymph node metastasis.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2003年第8期718-720,共3页
Journal of Third Military Medical University
