摘要
目的 :探讨非小细胞肺癌 (NSCLC)患者血清MMP 2、MMP 9水平与肿瘤转移的关系。 方法 :采用抗人MMP 2、MMP 9单克隆抗体 ,用ELISA法检测 72例非小细胞肺癌患者及 2 0例健康志愿者血清MMP 2和MMP 9水平。 结果 :NSCLC患者血清MMP 2和MMP 9含量显著高于正常对照组。NSCLC有转移组血清MMP 2和MMP 9水平显著高于NSCLC无转移组。 结论 :血清MMP 2和MMP 9浓度可作为预测非小细胞肺癌转移的指标。
Objectives:To investigate correlation of serum total MMP 2,MMP 9 levels with human non small cell lung cancer(NSCLC) metastasis, and to evaluate the clinical value. Methods:Serum total MMP 2,MMP 9 levels were detected in 72 patients with human non small cell lung cancer and 20 healthy volunteers by ELISA with monoclonal antibody against human total MMP 2,MMP 9. Results: Mean levels of MMP 2,MMP 9 were significantly elevated in cancer samples compared with normal serum( P <0.01). A significant difference was found between levels in the presence versus the absence of metastasis (MMP 2, P <0.05,MMP 9, P <0.01). MMP 2,MMP 9 levels in the sera in NSCLC metastasis group, did not show significant correlation with sex, age, or tumor histotype( P >0.05). Conclusions:Serum total MMP 2,MMP 9 levels may provide prognostic information of NSCLC metastasis.
出处
《医学研究生学报》
CAS
2003年第3期197-198,202,共3页
Journal of Medical Postgraduates
