摘要
目的:观察伊贝沙坦对原发性高血压患者肾脏的保护作用。方法:给予40例原发性高血压伴轻度肾功能不全患者伊贝沙坦150mg,1次/d,观察3个月,对服药前、后血压,心率,血尿素氮、肌酐、尿酸、钾、钠、氯,血糖等指标作对比分析。结果:伊贝沙坦治疗后收缩压、舒张压均明显下降(P<0.01),血肌酐、尿素氮下降显著(P<0.05,)而尿微量白蛋白(microalbuminuria,MA)和免疫球蛋白G(IgG)的水平无变化,对血钾、钠及血糖代谢亦无明显影响(P>0.05)。结论:伊贝沙坦对原发性高血患者肾功能有保护作用。
Objective: To investigate the renal protective effects of irbesarton in patients with essential hypertension (HE). Methods: Forty EH Cases complicated with light insufficiency of renal function were treated by irbesarton with 150mg once a day for Smonths. The index of blood pressure, heart rate, blood urea nitrogen, blood uric acid, etc. were measured and compared before and after the treatment. Results: After the treatment of irbesarton both systolic and diastolic pressure were significantly decreased (P<0. 01),blood creatinine and blood urea nitrogen level were also decreased (P<0. 05). In contrast, irbesarton had no effect on the level of microalbuminuria (MA) and blood IgG, the metabolism of blood glucose and level of blood K and Na (P>0. 05). Conclusion: It is suggest that irbesarton can protect the renal function in patients with essential hypertension
出处
《心血管康复医学杂志》
CAS
2003年第2期138-140,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
