摘要
目的:探讨硝苯地平控释片、赖诺普利单独治疗和联合治疗对高血压病患者肾功能的影响。方法:72例高血压病患者随机分为3组:硝苯地平控释片组(30 mg,qd,24例);赖诺普利组(10 mg,qd,24例);硝苯地平控释片和赖诺普利联合治疗组(硝苯地平控释片30mg,qd,赖诺普利(10 mg,qd,24例),疗程24周。治疗前、后观察肾功能指标变化。结果:①硝苯地平控释片、赖诺普利及联合治疗组高血压病患者治疗后均能显著降低血压(P<0.01)及尿蛋白的排泄量。但联合治疗组降低尿蛋白排泄的幅度比硝苯地平控释片组、赖诺普利组明显高,而硝苯地平控释片组和赖诺普利组之间差异无统计学意义(P>0.05)。②治疗后,肾小球滤过率在联合治疗及赖诺普利组明显增高,而硝苯地平控释片组无明显变化。⒊三组治疗后尿蛋白下降幅度与血压下降幅度均无显著相关。结论:硝苯地平控释片、赖诺普利长期单独治疗均可减少蛋白尿,保护肾功能,两药联合治疗对减少蛋白尿、保护肾功能有一定相加作用。
Objective：To examine the effect of Nifedipine Controlled Released Tablets and Lisinopril on renal function in patients with essential hypertension（EH）. Methods：Seventy two cases with EH were randomly divided into three groups ：Nifedipine Controlled Released Tablets group（30mg qd, n = 24 ）, Lisinopril group （10 mg qd, n = 24 ）and combined treatment group （Nifedipine Controlled Released Tablets 30rag qd Lisinopril lOmgqd,n =24）. Treatment lasted for 24 weeks. Parameters of renal function were measured before and after treatment. Results： After treatment, urinary total protein and albumin significantly decreased in all the three groups （P 〈 0. ol ）. The decrease extent in the combined treatment group was higher than that in the Nifedipine Controlled Released Tablets and Lisinopril groups （P 〈0.01 ） ,while no significant difference was found between amlodipine and Lisinopril groups （P 〉0. 05 ）. Combined treatment and Lisinopril alone also significantly increased the renal corpuscle filtration rate （ P 〈 0.05 ）, but no significant change was observed in the Nifedipine Controlled Released Tablets group （ P 〉 0.05 ）. No significant correlation between the decrease extent of urinary albumin and that of SBP or DBP was found among all the three groups （ P 〉 0.05 ）. Conclusions： The data suggested that Nifedipine Controlled Released Tablets combined with Lisinopfil treatment should has additive effect on the decrease of urinary albumin excretion and protection of renal function.
出处
《中国民康医学》
2006年第15期635-637,共3页
Medical Journal of Chinese People’s Health
关键词
高血压
肾功能试验
硝苯地平控释片
赖诺普利
Hypertension
Kidney function tests
Amlodipine Lisinopril
Nifedipine Controlled Released Tablets
