摘要
观察缬沙坦对肝硬化患者肝血流动力学的影响。26例肝硬化患者,给予血管紧张素ⅡⅠ型受体拮抗剂缬沙坦80mg qd,疗程1个月,于治疗前后检查肝血流动力学各项指标变化。发现经缬沙坦治疗后,肝硬化患者的肝血流动力学的各项指标均有不同程度的变化,总体表现为肝内血管阻力降低,肝窦内压下降,肝脏有效灌流增加,肝脏供血明显改善。缬沙坦应用于肝硬化患者,可明显改善肝硬化患者的血流动力学,增加肝脏血液灌流。
To study the effect of valsartan on liver hemodynamics in liver cirrhosis patients. 26 liver cirrhosis patients were treated with valsartan 80mg/day for 1 month. Before and after treatment, the parameters of the vascular's diameter(D) ,velocity(V) , flow quantity(Q) ,pulsatil index(PI) ,resistant index(RI) .congestion index(CI) were measured by Color Doppler Ultrasonography. The Portal vein (PV), superior mesenteric vein (SMV), spleen vein (SPV), right liver arteria(RHA), spleen arteria(SPA) were tested. After treated with valsartan for 1 month, the liver hemodynamics of the patients were changed remarkly. PV and SMV' s diameter were reduced( P < 0.05) , the velocity and flow quantity of PV and SMV were higher than befor ( P < 0.05 or P < 0.01). PV, SMV and SPV' s CI were reduced remarkly ( P < 0.05 or P < 0.01) , the velocity and flow quantity of KHA were improved ( P < 0.01), RI and PI were both reduced ( P < 0.01) . Though the SPV and SPA's diameter-,velocityAflow quantity were not changed much, but the RI and PI of SPA were reduced ( P < 0.05 or P < 0.01) . Valsartan can remarkly reduced the liver vascular' s inside - resistance and sinusoidial pressure in liver cirrhosis patients, thus remarkly improved the liver blood perfusion. Liver hemodynamics were great improved by valsartan, in liver cirrhosis patients.
出处
《临床肝胆病杂志》
CAS
北大核心
2003年第2期79-81,共3页
Journal of Clinical Hepatology
关键词
肝硬化
肝血流动力学
缬沙坦
liver cirrhosis
liver hemodynamics
valsartan
