摘要
目的探讨两种不同剂量缬沙坦降低肝硬化门静脉高压的疗效。方法将肝硬化门脉高压患者40例随机分为两组,每组20例。一组口服缬沙坦40m g/d,另一组口服缬沙坦80m g/d,疗程2周。治疗前后应用彩色多谱勒超声仪分别测量门、脾静脉内径和最大血流速度。结果治疗后两组患者门、脾静脉的内径下降,血流速度增快,用药前后比较,差异有统计学意义(P<0.01)。而治疗后两组上述指标比较,差异无统计学意义(P>0.05)。结论两种不同剂量缬沙坦降低肝硬化门静脉高压的疗效相同。
Objective To explore effects of different doses of valsartan on alleviation of portal hypertension in patients with cirrhosis.Methods 40 liver cirrhosis patients with portal hypertension were randomized to be either treated with valsartan（40mg/d） or with（80mg/d）.The effectiveness of the medicine was evaluated by measuring diameter of portal vien（DPV）,velocity of the blood flow in the portal vien（VPV）,diameter of splenic vien（DSV） and velocity of the blood flood of splenic vein（VSV） with Doppler before and after 2-weeks＇ treatment.Results The diameters of portal and splenic veins were significantly decreased.whereas the velocities of the blood flow in portal and splenic veins were significantly increased following either low or high dose of valsartan treatment.However there was no statistically significant difference between low dose or high dose treatment.Conclusion Valsartan（40mg/d） is as effective as valsartan（80mg/d） in reducing portal pressure in patient with portal hypertension resulted from liver cirrhosis.
出处
《同济大学学报（医学版）》
CAS
2010年第5期99-101,共3页
Journal of Tongji University(Medical Science)
