摘要
为开发新型手性铝锂试剂,探讨双不对称诱导效应,选用含杂原子的光学活性氨基醇为辅助配体,与1,2,5,6 二丙酮甘露醇共同修饰LiAlH4,对潜手性芳酮进行不对称还原,得到光学活性醇;通过与α D 乙酰氧基 L 丙酰氯生成非对映异构体酯,经气相色谱分析,对映体过量在43 6%～77 7%之间。结果表明辅助配体的绝对构型、空间位阻、β位杂原子对光学产率均有影响。
Lithium aluminum hydrides modified with 1,2,5,6diisopropylidene mannitol and βdialkylaminoalcohol were used to reduce acetophenone or propiophenone to yied corresponding optically active alcohol which were converted to diastereoisomers with αacetylLpropionyl chloride. Gas chromatog, analysis showed that the optical yieds of asymmetric reductions fell between 43.6%-77.7 %.
出处
《西南师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2003年第2期243-246,共4页
Journal of Southwest China Normal University(Natural Science Edition)
基金
国家自然科学基金资助项目(29372038)
国家教委博士点基金资助课题.
