摘要
目的 检测慢性肾功能衰竭 (CRF)患者血硒含量并探讨其临床意义。方法 测定40例CRF患者与 2 0例对照组的血浆硒含量、血清肌酐、尿素氮、血脂、白蛋白、尿蛋白和血压等指标 ,并分析血硒与其他参数的关系。血硒测定采用催化极谱法。结果 CRF非透析组和血液透析组血硒含量均明显低于对照组 [( 1.2 4± 0 .6 2 ) μmol/L和 ( 1.2 7± 0 .6 2 ) μmol/L对 ( 1.6 9± 0 .5 0 )μmol/L] ,P <0 .0 5 ,而两组之间血硒含量比较无显著性差异 (P >0 .0 5 )。直线回归和相关分析显示 ,非透析组血硒含量与血清肌酐 (r =-0 .912 ,P <0 .0 1)、总胆固醇 (r =-0 .6 98,P <0 .0 5 )、甘油三酯 (r =-0 .818,P <0 .0 1)、收缩压 (r =-0 .85 9,P <0 .0 1)、舒张压 (r =-0 .82 7,P <0 .0 1)和尿蛋白 (r =-0 .90 2 ,P <0 .0 1)呈显著负相关 ,而与血清白蛋白 (r =0 .90 7,P <0 .0 1)呈显著正相关。结论 缺硒与CRF的发生与发展相关 ,在CRF的一些异常表现中可能占有重要地位 ;缺硒可能作为一个重要的非免疫性肾损害因素 ,通过削弱机体的抗氧化能力而参与导致或者加重CRF。
Objective To determine the status of plasma selenium (Se) in patients with chronic renal failure (CRF) and to explore its clinical significance.Methods Plasma Se, serum creatinine (Cr), blood urea nitrogen (BUN),serum total cholesterol (TC) and triglycerides (TG), serum albumin (Alb), urinary protein contents and blood pressure were measured in 40 patients with CRF as well as in 20 healthy controls. The relation between above parameters and the change of plasma Se was analyzed by multiple logistic regression analysis.Results The levels of plasma Se in both hemodialysis patients and the patients without hemodialysis were significantly lower than those in healthy controls[(1.24±0.62)μmol/L vs(1.69±0.50)μmol/L],P<0.05;(1.27±0.62)μmol/L vs (1.69±0.50)μmol/L,P< 0.05respectively]. However, the plasma Se level was not different between no dialyzed patients and hemodialysis patients. However, the plasma Se level was not different between no dialyzed patients and hemodialysis patients[(1.243±0.618)μmol/L vs (1.270±0.615)μmol/L,P>0.05]Multiple logistic regression analysis showed that plasma Se content in no dialyzed CRF patients was negatively correlated with Cr(r=-0.912,P<0.01),TC(r=-0.689,P<0.05),TG(r=-0.818,P<0.01),systolic blood pressure(r=-0.859, P<0.01), diastolic blood pressure(r=-0.827,P<0.01), and urinary protein content(r=-0.902,P<0.01),and it was positively related to Alb(r=0.907,P<0.01). Conclusions Plasma Se deficiency may be related to pathogenesis and progress of pathologic changes in CRF. It may play an important role on some uremia abnormalities and may be an important no-immune factor contributing to pathogenesis or worsening pathologic changes of CRF through weakening body's antioxidative capacity.
出处
《临床内科杂志》
CAS
北大核心
2003年第2期93-95,共3页
Journal of Clinical Internal Medicine
