摘要
为探讨微量元素硒与肾脏病的相关性,采用催化极谱法对42例肾脏病患者血、尿硒含量进行测定,并与20例正常对照者比较。结果发现(1)肾脏病组血硒含量明显低于对照组(P<0.05)。(2)原发性肾病综合征组和肾功能衰竭组血硒含量均明显低于对照组(P<0.005和P<0.05),而尿石症组与对照组比较无显著性差异(P>0.05)。(3)肾功能异常组血硒含量明显低于肾功能正常组(P<0.001)。(4)肾脏病患者血硒含量与血浆粘度(r=-0.805,P<0.01),高切变率(230_s^(-1))全血粘度(r=-0.846,P<0.01),低切变率(9.69_s^(-1))全血粘度(r=-0.828,P<0.01)和尿蛋白量(r=-0.503,P<0.05)呈显著负相关性,与血清白蛋白(r=0.661,P<0.01)呈显著正相关,但与血清胆固醇(r=0.169,P>0.05)无相关性。(5)肾脏病患者尿硒含量与对照组比较无显著性差异(P>0.05)。结论:肾脏是缺硒损伤的靶器官之g 一,缺硒可能作为一个重要的非免疫性因素,通过削弱机体的抗氧化能力而参与导致或加重原发性肾病综合征和肾功能衰竭。
To evaluate the relationship between microelement selenium and renal diseases, serum selenium content and urinary excretion rate of selenium in 42 patients with renal diseases and 20 normal control were measured. Results: (1)serum selenium content in group of renal diseases was lower than normal control (1,401±0.664μmol/L vs 1.747±0.536μmol/L, P<0.05), (2)Serum selenium contents in two groups of primary nephrotic syndrome and renal failure were all lower than normal control (1. 285±0. 271μmol/L vs 1.747±0. 536μmol/L, P<0.005;1.274±0.756μmol/L vs 1. 747±0. 536μmol/L, P<0.05 respectively). But serum selenium content was not different in group of urinary calculus than normal control (1.722±0.708μmol/L vs 1.747±0.536μmol/L,P>0.05). (3)The content of serum selenium was significantly lower in group of renal function impairment(Scr>132. 5μmol/L)than in group of normal renal function(1. 196±0.327μmol/L vs 1. 534±0.225μmol/L,P<0.001). (4)Serum selenium content in patients with renal diseases was negative correlated significantly with plasma viscosity( r = - 0. 805, P < 0. 01), whole blood viscosity at the shear rate of 230s-1 (r= -0.846,P<0.01)and 9.69s-1(r = - 0. 828, P<0. 01)and proteinuria( r = -0.503, P < 0.05) and it was positively related to serum albumin (r = 0. 661, P<0. 01), but not with serum cholesterol (r = 0.169,P>05). (5)Urinary excretion rate of selenium was not different in patients with renal diseases than normal control(P>0. 05). Conclusion: Kidney is one of damaging target organs caused by serum selenium deficency. To lack selenium may be an important no - immune factor resulting in or worsening primary nephrotic syndrome and renal failure through weakening body's antioxidative capacity.
出处
《湖北民族学院学报（医学版）》
1998年第1期1-5,共5页
Journal of Hubei Minzu University(Medical Edition)
基金
恩施自治州科委科学基金
关键词
肾疾病
硒
肾病综合征
肾功能衰竭
renal diseases
selenium
primary nephrotic syndrome
renal failure
