摘要
根据天然海藻糖酶抑制剂的结构设计了一类吡啶甲基亚氨基噻 ( )唑烷化合物 ,通过吡啶甲基异硫氰酸酯和相应的胺反应 ,然后在盐酸或黄色氧化汞条件下关环 ,合成了吡啶甲基亚氨基噻唑烷和唑烷 ,其结构得到 IR、1H NMR、HRMS的确证。测试了化合物对昆虫 (家蝇 )飞行的抑制能力。
Based on the structure of Trehazolin, one of natural trehalase inhibitors, pyridinylmethylimino thiazolidine and oxazolidine compounds were designed and synthesized through reaction of pyridinylmethyl isothiocyanate with appropriate amine and followed by cyclization under HCl and HgO. Their structures were confirmed by using IR, 1H NMR, HRMS. The insect flight inhibitory bioactivity was given.
出处
《农药学学报》
CAS
CSCD
2003年第1期27-33,共7页
Chinese Journal of Pesticide Science
基金
国家 8 6 3资助项目 (2 0 0 1AA2 35 0 11)
上海市化学生物学 (芳香杂环 )重点实验室支持项目
关键词
噻唑烷
恶唑烷
合成
生物活性
异硫氰酸酯
thiazolidines
oxazolidine, synthesis
bioactivity
isothiocyanate
