摘要
本文报道顺氯氨铂在6例肿瘤患者体内的药代动力学参数及尿药排泄量。顺氯氨铂80mg/m^2静脉滴注,采用衍生化高效液相色谱法测定血药浓度和尿药浓度。结果表明顺氯氨铂在血浆中的衰减为二室开放模型,t(1/2)α为0.44h,t(1/2)β为21.10h,给药后7、24h和5天内的尿药排泄量,分别为给药量的10～19％,11～20％,14～25％。提示为避免蓄积中毒,临床用药疗程间隔时间不宜短于2～2.5月。
Plasma and urine concentration of cisplatin were monitored in 6 male patients after 80mg/m^2 of cisplatin by 1 h infusions. Cisplatin was measured by derivative chromatography, high pressure liquid. Plasma levels of cisplatin decayed in a biphase mode, with an initial half-life of 17 to 36 min and a secondary phase ranging from 18 to 23 h. Urinary excretion was incomplete,10-19% of dose was excreted in the first 7h. By 24 h, only 11-20% was excreted, after 5 days, only 14-25% was recovered. It is recommended that courses of cisplatin be administered no more frequently than every 2 to 2.5 months to reduce the risk of cumulative toxicity.
出处
《贵阳医学院学报》
CAS
1992年第2期100-103,共4页
Journal of Guiyang Medical College
关键词
抗癌药
顺氯氨铂
药代动力学
cisplatin
pharmacokinetics
chromatography
high pressure liquid
