摘要
目的 :探讨川芎嗪对大鼠腹膜透析模型腹膜形态及功能的影响。方法 :将 30只 SD大鼠随机分为对照组、含质量分数为 4.2 5 %的葡萄糖腹膜透析液 (腹透液 ,HGC)组及含川芎嗪腹透液 ( HGL)组 ,实验周期45 d。结果 :HGC组大鼠腹膜间皮细胞脱落 ,间皮下基质较对照组明显增多 ; 型胶原、纤维连接蛋白 ( FN)沉积明显增多 ;腹腔超滤量显著低于对照组。HGL 组间皮细胞基本完好 ;间皮下基质包括 型胶原、FN沉积明显低于 HGC组 ;腹腔超滤量显著高于 HGC组。结论 :长期使用 4.2 5 %葡萄糖腹透液可损伤腹膜结构和功能 ;川芎嗪能显著减少基质蓄积 ,改善腹膜结构 ,增加超滤 ,提高透析效能。
Objective:To investigate the effect of Ligustrazine(川芎嗪)contained peritoneal dialysate on rat peritoneal structure and function.Methods:Thirty SD rats were randomly divided into three groups.Except of control group,the other two groups received daily intraperitoneal injection of 25 ml of 4.25% glucose peritoneal dialysate (HGC group) or HGC plus 40 mg/L Ligustrazine (HGL group) for 45 days.Results:In HGC group,mesothelial cells detached from peritoneal membrane.The accumulation of Ⅰ type collagen and fibronectin on peritoneal membrane increased significantly comparing with that of control group.The drainage volume was significantly lower as compared to control group(P<0.05).However,in the HGL group,the accumulation of Ⅰ type collagen and fibronectin on peritoneal membrane decreased significantly comparing with that of HGC group,drainage volume was significantly higher as compared to that of HGC group (P<0.01).Conclusion:Ligustrazine may reduce the damage of the peritoneum caused by the hypertonic dialysis solution,and improve peritoneal structure and function during longterm peritoneal dialysis.
出处
《中国中西医结合急救杂志》
CAS
2003年第2期70-73,共4页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
卫生部临床学科重点科研基金资助 ( 970 40 2 2 8)
广东省自然科学基金资助 ( 0 0 1380 )
