摘要
目的研究 1 5Hz磁场对大鼠脑创伤的影响。方法采用大鼠局灶性左脑创伤模型 ,每天对大鼠头部进行正弦交变磁场 ( 1 5Hz、1 8mT)刺激 2h ,分别作用 3d或 8d ,同时设立对照组。双盲法病理切片观察。结果与对照组相比 ,磁场组的炎细胞反应减轻 ,神经元变性坏死程度减轻 ,8d时更为明显 ;远离创伤灶的皮层二、三层出现深染的呈长形 (或变形 )的特殊神经元 ,且磁场组的这种特殊神经元的数量和分布面积均明显高于对照组 ,尤以 8d时更为显著。结论所用ELMF可在一定程度上促进脑创伤的恢复 ,远离创伤区的特殊神经元的产生机制及其在脑创伤后恢复过程中的作用 。
Objective To examine the effect of extremely low frequency magnetic field (ELMF) on the brain trauma in rats. Method Using the focal left brain cortex contusion model, rats were divided into two groups, ELMF group(3 d and 8 d) and control group(3 d and 8 d), ELMF stimulations were given after the brain trauma, provided by a coil ( Ф10 cm ) which was driven by 15 Hz sinusoidal signals so that ELMF strength of 18 mT at the midpoint was obtained. The morphologic changes were observed in these groups. Result As compared with the control group, the extent of the inflammitory reaction and the neuronal damage was apparently lighter in magnetic field group, especially in 8 d group. At the far away region from the injured brain area, the neuronal shape was changed, and the amount of this special neurocyte was larger in magnetic field group than that in control group, especially in 8 d group. Conclusion ELMF stimulation in the present study may alleviate the brain injury reaction. Attention should be paid to the role of the special neurocyte during the brain injury.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2003年第1期75-76,共2页
Space Medicine & Medical Engineering
关键词
实验研究
磁场
极低频
磁效应
脑损伤
magnetic field
extremely low frequency
magnetic effects
brain injury
