摘要
采用乳化交联法制备壳聚糖载 5 -氟尿嘧啶微球 .研究了乳化剂 ,有机分散介质、交联反应时间、戊二醛用量、壳聚糖浓度和 5 -氟尿嘧啶浓度对微球性能的影响 ,结果表明 :当以苯甲酸乙酯为有机分散介质 ,Span - 80用量 2ml,交联反应 90min ,戊二醛用量 2ml,壳聚糖浓度 1% ,5 -氟尿嘧啶浓度1%时 ,所制壳聚糖微球粒径 10～ 5 0 μm ,载药率为 19.7% ,包药率 5 2 .3% ,为黄褐色致密球体 .
Chitosan microspheres loaded with 5-fluorouracil were prepared by crosslinking-emulsion method.The effect of the emulsifier,organic diffusion media,reaction time,glutaraldehyde amount,chitosan concentration and 5-fluorouracil concentration on microspheres property was investigated.The results showed that the optimum conditions for preparation were as follows:the ethyl benzoate as organic diffusion media,2ml Span-80,90min,2ml glutaraldehyde,1% chitosan and 1% 5-fluorouracil.At these conditions,the diameter,drug content and drug trapping efficiency of chitosan microspheres were 10～50μm,19.7% and 52.3%,respectively.
