摘要
目的 观察癌胚抗原 (CEA)在肺癌病人中对免疫系统的作用。方法 应用流式细胞仪检测 2 5例 (CEA)升高的肺癌病人、2 5例 (CEA)正常的肺癌病人和 2 5例 (CEA)正常的肺炎病人的外周血中CD4(TH)、CD8(TS)及CD4/。结果 CD4及CD4/CD8在 2 5例 (CEA)升高的肺癌病人中明显低于 2 5例 (CEA)正常的肺癌病人和 2 5例 (CEA)正常的肺炎病人 ,而CD8明显升高 ,差异有显著性。
Objective To observe the role of carcinoembryonic antigen (CEA) in the immunological function.Methods The CD 4(+) T cell,CD 8(+) T cell and CD 4(+)/CD 8(+) in the peripheral blood of 25 CEA positive patients with lung carcinoma,25 CEA negative patients with lung carcinoma and 25 CEA negative patients with pneumonia were determined by using flow cytometry. Results The CD 4(+) T cell and CD 4(+)/CD 8(+) were significantly decreased in 25 CEA positive patients as compared with 50 CEA negative patients, while the CD 8(+) T cell were much higher in 25 CEA negative patients than that of 50 CEA negative patients(P<0.01).Conclusions The CEA positive in pativents with lung carcinoma obviously suppressed the immunological function .
出处
《齐齐哈尔医学院学报》
2002年第12期1325-1325,1327,共2页
Journal of Qiqihar Medical University
关键词
肺癌
癌胚抗原
机体免疫系统
免疫学
Lung carcinoma Carcinoembryonic antigen (CEA) Immunology
