摘要
目的 应用口服钆喷替酸葡甲胺 (Gd DTPTA)溶液作为胃肠道阴性对比剂 ,以降低胃肠道背景高信号 ,提高磁共振胰胆管成像 (MRCP)的图像质量。方法 用 5 0ml药瓶将Gd DTPA溶液稀释成不同浓度 (分别稀释为 5倍、10倍、15倍、2 0倍 ) ,并设空白对照组 ,行常规及MRCP扫描 ,以选择最佳的对比剂浓度。对 15例疑有胰胆管系统疾病的病人行口服对比剂前后MRCP检查 ,对比剂为稀释 5倍的Gd DTPA溶液 ( 1 488g/L) 2 5 0ml,磁场强度为 1 5T。MRCP成像方法有二维单层快速自旋回波 (FSE)序列及半傅立叶单次激发快速自旋回波 (HASTE)序列。结果 实验部分结果表明稀释 5倍的Gd DTPA溶液T2 WI信号降低最明显 ,达 5 9 3 % ,HASTE序列信号强度降低 82 45 % ,单层MRCP时所有稀释倍数液体信号强度均下降达 90 %以上。所有病例口服对比剂后MRCP扫描胃及十二指肠内液体高信号均较前有明显下降 ,图像质量明显提高 ,以单层MRCP序列胃肠道液体高信号抑制最明显。口服Gd DTPA溶液前后 ,胆总管、胰管及胆囊结构的显示程度等级评分差异有显著性意义 (P <0 0 5 )。结论 稀释 5倍的口服Gd DTPA溶液是一种安全有效地降低胃肠道液体高信号强度。
Objective Using oral Gd-DTPA as a negative contrast agent to null the bowel signal during MR cholangiopancreatography (MRCP) to improve the quality of MRCP. Methods A phantom study was performed to select the optimal concentration of Gd-DTPA to be used as an oral negative contrast agent in MRCP. 15 patients suspected of biliary tract and pancreatic disease were performed with MRCP before and after using 250 ml oral contrast agents (1∶5 diluted Gd-DTPA, 1.488 g/L). All MR images were acquired using a 1.5 T whole body MR scanner (Vision Plus, Siemens). MRCP was acquired using two-dimensional single slice fast spin-echo sequence and HASTE (half-fourier acquisition single-shot fast spin echo) sequence. Results The phantom study showed that the dilution ratio 1∶5 of Gd-DTPA oral contrast agent was best in decreasing the signal intensity both in T 2WI (59.3%) and in HASTE sequence (82.45%). All the dilution ratio of Gd-DTPA oral contrast agent decreased the signal intensity up to 90% on single slice MRCP. In all the patients the high signal intensity from the stomach and intestinal fluid was completely suppressed. The depictions of common bile duct and pancreatic duct were markedly improved by the oral contrast agent (P<0.05). Conclusion 1∶5 diluted (1.488 g/L) oral MR contrast agent Gd-DTPA can be an effective and safe negative contrast agent in eliminating signal intensity of the gastrointestinal tract, thus improving the depiction of the biliary system in MRCP.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2003年第1期75-79,共5页
Chinese Journal of Radiology
