摘要
目的研究钆喷酸葡胺(Gd-DTPA)注射液和硫酸钡(BaSO4)混悬液在改善磁共振胰胆管成像(MRCP)质量方面的应用价值。方法体外实验中,研究MR信号强度与两种对比剂不同浓度之间的关系,拟定出最佳的浓度配比。临床研究中,将受检者随机分组,行口服对比剂前后MRCP检查,并配合MR增强扫描,对照研究不同浓度的Gd-DTPA和BaSO4对MRCP图像中胃肠道液体信号的影响。结果体外实验表明,浓度稀释10倍的Gd-DTPA和浓度为100%(W/V)的BaSO4抑制液体信号的效果理想;临床研究表明,所有病例口服Gd-DTPA稀释液后胃肠道内液体高信号均有明显下降(P<0.05),而BaSO4混悬液抑制效果欠佳。结论口服稀释Gd-DTPA注射液对胃肠道液体信号的抑制效果较好。口服稀释100倍的Gd-DTPA注射液并配合MR增强扫描,MRCP成像效果最佳。
Objective To assess and compare the effectiveness of gadolinium diethylenetriamine pentacetic acid （Gd-DTPA） solution and barium sulfate （BaSO4） suspension with different concentrations in improving the imaging quality of magnetic resonance eholangiopancreatography（MRCP）. Methods The phantom study was carried out to determine the optimal concentration of Gd-DTPA and BaSO4 suspension used as an oral negative contrast agent in MRCP. The patients were grouped randomly and performed MRCP before and after using oral contrast agents in combination with intravenous injection of contrast agents. A comparison of the influence of BaSO4 suspension and Gd-DTPA with different concentrations on the signal intensity of the fluid in gastrointestinal tract on MRCP images was made. Results The phantom study showed that the dilution ratio 1：10 of Gd-DTPA solution and 100% （W/V）BaSO4 suspension were the optimal concentrations in decreasing the signal intensity. In all patients the high signal intensity of the gastrointestinal fluid was completely suppressed after oral administration of Gd-DTPA diluted solution （P 〈 0.05）. However, the suppression effect of BaSO4 suspension was not ideal. Conclusion Gd-DTPA diluted solution may decrease the signal intensity of gastrointestinal liquid effectively. Oral administration of 1：100 diluted ratio of Gd-DTPA solution combined with Gd-DTPA intravenous injection may improve the imaging quality of MRCP.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2007年第1期103-107,共5页
Journal of Shanghai Jiao tong University:Medical Science
