摘要
目的 评价一种新近由磁石为原料研制成功的超顺磁性口服磁共振对比剂D98A在腹部MRI诊断中的应用价值。方法 通过不同场强的MR机 ,对 80例受检者进行了平扫和服用D98A量 5 0 0～ 10 0 0ml的MRI检查 ,扫描序列包括T1WI、T2 WI和脂肪抑制 ,观察该对比剂的对比效果、分布情况及对腹腔脏器轮廓的勾画及副反应。结果 D98A对比剂易于受检者接受、安全性好、性能稳定、胃肠道充盈良好 ,在各种扫描序列下胃肠道均呈低信号对比状态 ,腹部脏器的勾画较平扫明显提高 ,使用D98A前后胃肠道显示率由平均约 10 % ,提高到约 89%。受检者均未出现副反应。结论D98A安全有效 ,有利于腹腔内实质脏器的勾画 ,可提高胃肠道和腹腔内病变诊断的准确性。
Objective To evaluate the efficacy of D98A,a newly developed superparamagnetic oral MRI contrast agent,in the diagnosis of abdomen.Methods Plain and contrast MRI after taking 500～1000 ml D98Ain 80 patients were performed by using different field strength MR scanners,and the sequences included T 1WI,T 2WI,and fat suppressed sequences.The contrast effect,distribution,influence on demonstration of contours of abdominal organs,and side effects were studied concerning this suspension.Results It showed that this oral contrast agent had good security character,wide consideration area,low cost,good contrast effect,and high value of clinical application.The gastrointestinal tracts appeared as hypointensity on various MR sequences,and thus,made them easy to be identified.The margins of abdominal organs were easier to be located after taking the contrast,and the distinction had statistical denotation.The demonstration rate of gastrointestinal tracts was raised from 10% to 89% after using D98A.There were no side-effects in all patients. Conclusion D98A is safe and effective in facilitating the localization of the abdominal organs.It can improve the accuracy in delineating the gastrointestinal tracts and in diagnosing the lesions of abdominal organs.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2004年第6期659-661,共3页
Chinese Journal of Radiology
基金
2 0 0 0年山东省技术创新项目 2 0 0 0 110 0 70 18
2 0 0 0年山东省优秀中青年科技发展基金 2 0 0 0 14 4
关键词
口服磁石
MRI
对比剂
D98A
临床试验
药物评价
Magnetic resonance imaging
Magnetite
Contrast media
Drug evaluation
Clinical trials
