摘要
目的 研究盐酸丁卡因脂质体以及脂质体凝胶的制备方法 ,并考察脂质体及脂质体凝胶对药物释放的影响。方法 乙醇注入法制备盐酸丁卡因脂质体 ,研和法制备脂质体凝胶 ,透析法测定盐酸丁卡因脂质体以及脂质体凝胶中药物的释放。结果 采用乙醇注入法制备盐酸丁卡因脂质体 ,包封率大于 80 % ,脂质体及脂质体凝胶中药物释放均符合Higuchi方程 ,分别为Qt= 0 .7662 +7.5 88t1/2 和Qt = 4.40 81+5 .0 5 9t1/2 ,游离药物凝胶中药物释放符合一级方程 ,为Ln(Q∞ Qt) =18.5 3 4.899t。结论 盐酸丁卡因脂质体凝胶剂对药物有缓释作用 。
OBJECTIVE To study the methods of preparation of hydrochloride tetracaine liposome and liposome gel and to determine the liberation of drug from them. METHOD Prepare the hydrochloride tetracaine liposome by ethanol injection method,prepare hydrochloride tetracaine liposome gel by mixing method,and determine the liberation of drug by dialysis.RESULTS The encapsulation ratio of liposome is larger than 80%. The rate of drug release from liposome and liposome gel fitted with Higuchi equation, and from free drug gel fitted with one order equation. The equations are Q t = -0.7662 + 7.588 t 1/2 ,Q t = -4.4081 + 5.059 t 1/2 and Ln(Q ∞ Q t) = 18.53 - 4.899 t separately.CONCLUSION The hydrochloride tetracaine liposome gel has reduced the drug release significantly, it can prolong the function duration.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2003年第1期37-40,共4页
Chinese Journal of Modern Applied Pharmacy
关键词
盐酸丁卡因
脂质体
凝胶
制备
释放
测定
hydrochloride tetracaine
liposome
gel
preparation
drug release
