摘要
目的对盐酸利多卡因（lidocaine hydrochloricde，LDH）脂质体凝胶剂体外透皮量、皮肤层滞留量进行评价。方法超声法制备LDH脂质体，再用卡波普为基质制成凝胶剂；以体外经皮渗透释药法，比较LDH脂质体凝胶剂及LDH凝胶剂中的经皮渗透规律。结果平均包封率为（83．4±1．81）％；LDH凝胶剂的渗透符合Higuchi方程，其中脂质体凝胶剂24h内药物渗透速率为770．32μg·h^-1，明显高于游离药物凝胶渗透率280．01μg·h^-1。结论载药脂质体凝胶剂可显著促进药物经皮吸收，为经皮吸收药物的理想载体。
Objective To evaluate the cutaneous permeation kinetics of lidocaine hydrochloride liposomal gel. Method The LDH liposome was prepared by the reverse-phase evaporation and ultrasound method, the carbopol was added as a support base for the preparation of the liposomal gel. The permeation rate of LDH liposomal gel was assessed by Eranz -diffiusion, and compared with convintional hydrogel. Results Mean entrapment efficiency was（83.4±1.81）%, The permeation rate （770. 32 μg·h^-1）of liposome gel was significantly higher than that （280.01μg·h^-1） of conventional gel in 24 h in vitro The release pattem of drugs from two-type gels were coincident with Higuchi function. Conclusion Liposomal gel has the ability to enhance LDH transcutaneous permeation It is effective vehicle for transdermal thera-peutic dnugs.
出处
《国际医药卫生导报》
2008年第20期63-65,共3页
International Medicine and Health Guidance News
关键词
利多卡因
脂质体
凝胶剂
包封率
Lidocaine Liposome Gel Entrapment efficiency
