摘要
目的 :探讨SOD在高原地区体外循环中的心肌保护作用。方法 :将 2 0只杂种犬随机分成A组 (对照组 ,n =10 )和B组 (试验组n =10 ) ,模拟临床浅低温体外循环 ,B组停搏液中加入SOD 6万U/ 10 0ml,分别于CPB前、30min、 6 0min及CPB后 2h取样测定心肌组织中的MDA ,冠状静脉血中CPK浓度以及心肌组织的病理改变 ,比较两组的差异。结果 :A组心肌组织中MDA含量在CPB6 0min及CPB后 2h明显高于B组 ;A组冠状静脉血中CPK浓度在CPB6 0min及CPB后 2h明显高于B组 ;CPB后A组心肌组织发生了更明显的损伤性病理改变。结论 :SOD具有减轻高原体外循环心肌再灌注损伤的作用。
Objective:To study the protective effect of SOD on the myocardium during CPB at high altitude. Methods:Twenty hybrid dogs were randomly divided into two groups: control group(group A, n=10) and SOD group (group B, n=10). Dog models of CPB with hypothermia were established, in which serum malmondialdehyde (MDA) level, creatine phosphokrnase (CPK) concentration in coronary venous blood and the pathologic changes of myocardium were respectively measured before CPB, during CPB(at the 30th minute and 60th minute) and two hours after CPB. Results:Comparison between the two groups revealed significant higher MDA levels and CPK concentration in group A during CPB (at the 60th minute) and two hours after CPB, and more serious pathologic changes of myocardium were observed in group A. Conclusion:SOD cnd abate the ischemia-reperfusion injury of myocardium during CPB at high altitude.
出处
《西南国防医药》
CAS
2003年第1期12-14,共3页
Medical Journal of National Defending Forces in Southwest China
