摘要
目的:探讨高压氧(HBO)预处理对进驻高原人体超氧化物歧化酶(SOD)和丙二醛(MDA)的影响。方法:①海拔3700m的20名习服男青年,在HBO预处理前(对照组)、预处理5次(A组,10人)和预处理2次(B组,10人)后的第2天、8天和第2天、5天作自身对比运动负荷实验,运动结束后检测血中超氧化物歧化酶(SOD)、丙二醛(MDA);②29名青年分为HBO组(11人)和对照组(18人),HBO组于进入高原前2天在平原(海拔1400m)接受HBO预处理,每天一次,连续2天,历时5天同时乘车进驻海拔5200m,到达后第5天清晨空腹采静脉血检测SOD、MDA指标;③20名青年自海拔1400m乘车抵达海拔3700m,分为HBO组(10人)和对照组(10人),HBO组连续HBO预处理3天,每天一次,第4天两组历时1天同时乘车进驻海拔5380m,进驻第5天清晨空腹采静脉血检测SOD、MDA指标。结果:海拔3700m、5200m和5380m,HBO预处理组较对照组SOD增高,MDA降低,差别显著(P<0.01或P<0.05)。结论:HBO预处理可提高进驻高原者的抗氧化活力,改善高原低氧环境体内氧化与抗氧化之间的平衡紊乱,并可维持一定的时间,对于降低急性高原反应的发病率有很好的预防及治疗作用。
Objective： To explore the effects of hyperbaric oxygen （HBO） pretreatment on MDA and SOD level in immigration at high altitude. Methods：①20 male recruits who lived at 3 700m altitudes were divided into group A （n= 10） in which they received HBO pretreatment, once a day for 5 days and group B （n=10） in which they received HBO pretreatment, once a day for two days. And group A completed the exercise test after 2, 8 pretreatment days; group B did similar test after 2, 5 pretreatment days, then level of SOD and MDA were measured. ②29 youths who were at 1 400m altitudes were divided into HBO group （n= 11） and control group（n= 18）. The HBO group received HBO pretreatment once a day for 2 days then elevated 5 200m altitudes by bus together with the control group. Level of SOD and MDA were measured on the fifth exposed altitude day. ③20 youths, who had arrived at 3 700m altitudes from 1 400m by bus, were randomLy divided into HBO group（n= 10）and control group（n= 10）, HBO group received HBO pretreatment once a day for 3 days, then arrived at 5 380m altitudes by bus together with control group. Level of SOD and MDA were measured on the fifth exposed altitude day. Results： Level of SOD was increased in the HBO pretreatment group at 3 700m, 5 200m and 5 380m compared with that with control group, on contrast in level of MDA. There was a significant difference （P〈0. 01 or P〈0. 05）. Conclusions： HBO pretreatment can improve the condition between oxidation and antioxidant of the balance disorder at high altitude and it has a very good role to reduce the incidence of acute altitude reaction.
出处
《高原医学杂志》
CAS
2008年第3期1-4,共4页
Journal of High Altitude Medicine
