摘要
目的 探讨肝炎后门脉高压性胃病 (PHG)发病机制、门脉高压时肠道菌群的分布以及与内毒素之间的关系、药物治疗对肠道菌群和内毒素的影响。方法 选择 2 0 0 2 - 0 2～ 2 0 0 3- 12大连市第六人民医院住院的肝炎后肝硬化及门脉高压性胃病患者 ,均做电子胃镜、治疗前后大便菌群分析、鲎实验检测血浆内毒素 (LPS)。结果 门脉高压胃病组与肝炎后肝硬化组和对照组相比较 ,拟杆菌、双歧杆菌显著减少 ;而肠杆菌科细菌、酵母菌显著增加。门脉高压胃病组与肝炎后肝硬化组血内毒素较对照组均显著增加 (P <0 0 1)。结论 内毒素与肠道菌群产生异常变化可能对门脉高压性胃病的发病有直接或间接的影响。
Objective To investigate the changes of intestinal flora in patients with portal hypertensive,and the relationship between the disorder extent of flora and the levels of endotoxin in the blood.Methods Fecal flora of the subjects were quantitatively analyzed by Mitsuoka’ s methods.Meanwhile,plasma concentration of endotoxin was determined with the modified chromogenic limulus assay.Results The number of bacteriodes and bifidobacterium in portal hypertensive gastropathy group was significantly decreased compared with that of control group and cirrhosis group (P<0.001).However,the number of fecal enterobacteriaceae and yeasts in portal hypertensive gastropathy group was significantly increased compared with that of control group and cirrhosis group. The level of endotoxin in portal hypertensive gastropathy group was significantly increased compared with that of the other groups.Conclusion The data suggest that there are intestinal microdysbiosis and overgrowth of aerobic gram-negative bacillus in patients with portal hypertensive gastropathy,which might play an important role in the development of endotoxemia.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2004年第12期741-742,共2页
Chinese Journal of Practical Internal Medicine
关键词
门脉高压性胃病
肠道菌群
内毒素
贝飞达
PHG dysbiosis of intestinal flora Endotoxin Microecological products
