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雄激素受体异常激活与激素非依赖性前列腺癌的形成机制 被引量：2

Abnormally Activated Androgen Receptor and the Mechanism of Androgen-Independent Prostate Cancer
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摘要 前列腺癌进展的晚期常转变为激素非依赖性 ,包括雄激素受体拮抗剂在内的多种细胞外因子能够刺激其增殖。雄激素受体基因突变、多种途径引起的异常磷酸化激活和共激活物的调节失控等是激素非依赖性前列腺癌形成的主要促成因素。以雄激素受体为靶标可能成为晚期前列腺癌的有效治疗途径。 Most prostate cancers tend to enter androgen-independent proliferation at their advanced stages. Many kinds of extracellular factors can promote this proliferation, including androgen receptor blockers. The mutation of androgen receptor gene, abnormal phosphorylation and abnormal regulation of co-activators contribute to the formation of androgen-independent prostate cancer. Using androgen-receptor as a target may be an effective approach for the treatment of advanced prostate cancers.
作者 陈朝晖 肖传国
机构地区 华中科技大学同济医学院附属协和医院泌尿外科
出处 《医学分子生物学杂志》 CAS CSCD 2004年第5期309-312,共4页 Journal of Medical Molecular Biology
基金 国家自然科学基金 (No .3 960 0 14 6)
关键词 雄激素受体基因 激素非依赖性前列腺癌 激活 细胞外 晚期前列腺癌 有效治疗 拮抗剂 磷酸化 靶标 增殖 prostate cancer androgen receptor androgen-independence
分类号 R737 [医药卫生—肿瘤] R735 [医药卫生—肿瘤]
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参考文献22

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同被引文献32

  • 1张军,吕朝晖,母义明,潘长玉.前列腺癌原癌基因[J].医学综述,2006,12(12):725-727. 被引量：3
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医学分子生物学杂志
2004年 第5期

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