摘要
目的:观察枝管藻多糖(CF)对荷S_(180)小鼠的作用。方法:用不同剂量的枝管藻多糖ig荷S_(180)小鼠,采用物理和生物化学的方法测定其瘤重、脾指数、胸腺指数以及血清MDA含量和SOD活性。结果:低、中、高三个剂量的枝管藻多糖均能显著抑制小鼠S_(180)肉瘤的生长,其抑瘤率为27.83％～33.97％,以中剂量组的作用效果最显著;对荷瘤小鼠的脾指数、胸腺指数及外周白血细胞数量无显著性影响;枝管藻多糖能显著降低荷瘤小鼠血清MDA含量和显著提高其SOD活性。结论:枝管藻多糖的抗肿瘤作用可能与其抗氧化作用有关。
Objective Effects of fucoidan from Cladosiphon okamuranusa (CF)on mice bearing Siso were investigated. Methods Different concentrations of CF were given to mice bearing tumor by ig. The tumor weight, spleen index, thymus index and serum MDA content, serum SOD activity were detected by physical and biochemical methods. Results The growth of S180 tumor was inhibited significantly by CF in different concentrations. The inhibitory rate ranged from 27. 83% to 33. 97%. The highest inhibition rate occurred in the medium dosage. The spleen index, thymus index and leukocyte counts were not influenced obviously. The content of serum MDA was decreased remarkably and the activity of serum SOD was enhanced notably. Conclusion The mechanism of anti -tumor effects of CF may relate with its antioxidation.
出处
《中国海洋药物》
CAS
CSCD
2002年第6期16-19,共4页
Chinese Journal of Marine Drugs
关键词
枝管藻多糖
S180肉瘤
脾指数
胸腺指数
丙二醛
超氧化物歧化酶
Cladosiphon okamuranusa fucoidan (CF)
sarcoma 180(S180)
Spleen index
Thymus index
Malondialdehyde(MDA)
Superoxide dismutase(SOD)
