摘要
目的 了解丝素膜的血液相容性。方法 将致密丝素膜、多孔丝素膜和对照组的牛心包、蚀原海绵行复钙试验、溶血试验、血小板粘附试验。结果 复钙时间 :致密丝素膜较多孔丝素膜、牛心包、蚀原海绵延长 ,致密丝素膜与后三者之间有显著性差异 (P <0 0 1 ) ,后三者之间无显著性差异。溶血率 :致密丝素膜 3 2 8% ,多孔丝素膜2 0 2 % ,牛心包 0 1 9% ,蚀原海绵 0 2 8% ,均小于 5 % ,均不引起溶血。血小板粘附试验 :四种材料表面血小板均没有明显变形 ,致密丝素膜表面粘附的血小板较其余三种材料少。结论 丝素膜具有良好的血液相容性。
Objective To investigate the blood compatibility of silk fibroin membrane.Methods Recalcification test, hemolysis test and platelet adhesive test were conducted for compact silk membrane, polyporous silk membrane, bovine pericardium and collagen sponge. Results Recalcification time of compact silk membrane is longer than that of other three materials. The homolysis rate of compact silk membrane, polyporous silk membrane, bovine pericardium and collagen sponge was 3 28%, 2 02%, 0 19%, 0 28% respectively. The homolysis rate of all materials was less than 5%. It shows that the four materials did not lead to hemolysis. Platelet adhesive test shows that the surface of compact silk membrane had less platelet than that of other three materials. The platelets on surface of all four materials were without obvious malformations.Conclusion The silk membrane suggests good blood compatibility, and the compact silk membrane has anticoagulant effect.
出处
《中国血液流变学杂志》
CAS
2002年第4期266-269,共4页
Chinese Journal of Hemorheology
基金
国家自然科学基金 (编号 50 0 730 14 )
国家 86 3计划 (编号 2 0 0 1AA32 6 0 80 )资助课题
关键词
生物材料
丝素膜
血液相容性
biomaterials
silk membrane
blood compatibility
