摘要
利用相转变原理以及湿相浇铸法制备聚氨酯致密和多孔涂层.观察结果表明多孔样品的表面形貌如孔径等主要受质量分数和空气相对湿度的影响.为测试聚氨酯涂层的性能,将样品在Hank′s模拟体液中进行浸泡实验,并且对不同样品的亲水/疏水性以及血液相容性进行检测.结果表明在相转变过程中聚氨酯多孔涂层的孔径变化规则有序,并且孔径变化范围为1～30μm.在Hank′s模拟体液中浸泡3个月之后,聚氨酯多孔涂层表面基本没有变化并且涂层没有从基体表面脱落.接触角测量结果表明多孔涂层表面呈强疏水性.此外聚氨酯多孔涂层的血小板粘附量最少,并且延长了抗凝血时间,说明其具有良好的血液相容性.
With the principle of phase inversion, a wet-casting method was used to fabricate polyurethane （PU） compact or porous coatings. It is observed that the surface morphologies of porous coating such as the pore diameters were mainly affected by the concentration of solution and the relative humidity of air. In order to test the properties of PU coatings, experiments including immerging test in Hank＇s solution, measurement of hydrophilic/hydrophobic properties and blood compatibility were carried out. The results showed that the pore diameters of PU porous coatings were regular and the pore sizes were in the range of 1μm to about 30μm during the phase inversion process. After three months in Hank＇s solution, the surface of PU porous coatings hardly changed and no coatings flaked away from the substrates. The measurement of contact angle indicated that the surfaces of porous coatings came to be super-hydrophobic. Furthermore, PU porous coatings deposited the least platelets and prolonged the anticoagulation time. It is concluded that the PU porous coatings have excellent blood-compatibility.
出处
《大连理工大学学报》
EI
CAS
CSCD
北大核心
2007年第4期521-526,共6页
Journal of Dalian University of Technology
基金
国家"八六三"高技术研究发展计划资助项目(2002AA326010
2004AA32G110)
关键词
多孔涂层
表面形貌
血小板粘附
抗凝血时间
血液相容性
porous coating
surface morphology
platelet adhesion
anticoagulation time
blood compatibility
