摘要
背景:专家们认为改善抗凝血生物材料的血液相容性,可以明显提高抗凝血生物材料的抗凝血性能。目的:评价聚酯类和钛类抗凝血生物材料的血液相容性。方法:以文献检索的方法探讨聚酯类和钛类抗凝血生物材料对血液中红细胞、血小板、白蛋白、纤维蛋白以及凝血因子等的影响,并通过溶血试验、动态凝血试验、血小板黏附试验、血清蛋白吸附试验、复钙试验以及乳酸脱氢酶释放试验等分析聚酯类和钛类抗凝血生物材料的抗凝血性能,从而评估聚酯类和钛类抗凝血生物材料的血液相容性。结果与结论:聚酯类抗凝血生物材料及钛类抗凝血生物材料的溶血率明显降低,血小板黏附较少,白蛋白的吸附量增加,纤维蛋白原的吸附明显减少,复钙时间及凝血时间明显延长,表现出较高的抗凝血性能,具有良好的血液相容性,是较为理想的抗凝血生物材料。
BACKGROUND： Experts believe that the improvement of hemocompatibility of the anticoagulant biomaterials can significantly improve the anticoagulant properties of the anticoagulant biomaterials. OBJECTIVE： To evaluate the hemocompatibility of the polyester-based and titanium-based anticoagulant biomaterials. METHODS： The effect of polyester-based and titanium-based anticoagulant biomaterials on the level of red blood cells, platelets, albumin, fibrin and coagulation factors was explored through Searching the relative literatures. The anticoagulant properties of the polyester-based and titanium-based anticoagulant biomaterials were analyzed through the hemolysis test, dynamic blood coagulation test, platelet adhesiontest, serum protein adsorption experiment recalcification test and lactate dehydrogenase releasing test, thus the hemocompatibility of the polyester-based and titanium-based anticoagulant biomaterials was evaluated. RESULTS AND CONCLUSION： The hemolysis rate of polyester-based and titanium-based anticoagulant biomaterials was significantly decreased~ and the polyester-based and titanium-based anticoagulant biomaterials have less platelet adhesion and increased adsorption amount of albumin, and the fibdnogen adsorption was significantly reduced, the recalcification time and clotting time was significantly prolonged. The polyester-based and titanium-based anticoagulant biomaterials show a higher anti-clotting property, which are ideal anticoagulant biomaterials.
出处
《中国组织工程研究》
CAS
CSCD
2013年第8期1505-1512,共8页
Chinese Journal of Tissue Engineering Research
关键词
生物材料
生物材料学术探讨
抗凝血
血液相容性
血小板
纤维蛋白
白蛋白
聚氨酯
纯钛
钛氧薄膜
溶血率
复钙时间
biomater a s academ c d ,scuss on of b omater a s anticoagulant
hemocompatibility
platelets
fibrin
albumin
polyurethane
titanium
titanyl film hemolysis rate
recalcification time
