摘要
目的 :探讨经验方肾纤康汤对系膜增生性肾小球肾炎 (MesangialProliferativeGlomerulonephritisMsPGN)患者血清细胞外基质 (ExtracelluarMatrixECM )成分的抑制作用。方法 :6 0例MsPGN患者随机分成肾炎对照组、苯那普利组和肾纤康组 ,治疗前后采用放射免疫法检测血清层粘连蛋白 (LamininLN)和Ⅳ型胶原 (CollagenⅣCol-Ⅳ )并观察各组差异。结果 :MsPGN患者血清LN、Col-Ⅳ水平显著高于健康对照组 (P <0 .0 1)。肾纤康汤能明显下调MsPGN患者血清LN和Col-Ⅳ水平 (P <0 .0 1) ,其作用强度与苯那普利相近 (P >0 .0 5 )。结论 :肾纤康汤能减少MsPGN患者血清LN、Col-Ⅳ的水平 。
Objective:To investigate the intensity of inhibition of Shen XiangKang (SXK) decoctio on various ingredients of mesangial extracellular matrix (ECM) in Patiets of mesangial proliferative glomerulonephritis (MsPGN).Methods:Sixty patients of MsPGN diagnosed by renal biopsy were randomly divided into three groups:nephritis control group,benazepril group and SXK group.Blood Laminin (LN) and Collagen Ⅳ (Col-Ⅳ) were assessed by RIA before and after treatment to observe the differences of differcent groups.Results:The mean level of blood LN and Col-Ⅳ in MsPGN patients were markedly higer than that in healthy persons (P<0.01).SXK decoction could apparently down-regulate the lerel of serum LN and Col-Ⅳ (P<0.01) with the similar effect of benazepril (P<0.05).Conclusion:SXK decoction can reduce the level of LN and Col-Ⅳ in serum of Mesangial Proliferative Glomerulonephritis patients,its effect and mechanism need further study,
出处
《中国中西医结合肾病杂志》
2002年第11期643-644,656,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
