摘要
本文观察了脑损伤后不同时间大鼠脑水含量和脑皮质及血清钙含量变化,以及Nimodipine对外伤性脑水肿和钙含量变化的影响。结果表明,脑损伤后6h脑白质水含量巳明显增多,为79.87±0.58(P<0.01),伤后48h达峰值,为81.02±0.51:脑皮质水含量稍有增加。脑皮质及血清钙含量均有不同程度升高,以脑皮质升高较为明显,伤后48h高达24.12±10.22mmol/kg干脑,为对照值的1.8倍.应用Nimodipine治疗,可显著降低脑皮质钙含量,伤后立即接受治疗组为16.78±4.98mmol/kg干脑(P<0.05),脑水肿明显减轻,为78.98±0.89(P<0.01)。
The authors studied the changes of brain fluid content and calcium in the brain cortex and serum following brain injury in 100 wistar rats.Nimodipine was employed to show its effect on the traumatic brain edema and alterations of calcium in the brain cortex and serum. The experimental results showed that the water content of white matter increased 6 hours after brain injury significantly (P<0.01 ) .Its value was 79.87±0.58. And it reached its peaks 48 hours after trauma. The value was 81.02 ±0.51 at that period. The calcium contents in the brain cortex and serum elevated slightly after injury. The increment of calc-iumn in the brain cortex was more remarkably.Thei value was 24.12 ± 10.22 mmol/kg dry brain cortex 48 hours after trauma, which was 1.8 times of control value. Nimodipine revealed a effect on reducing calcium in the brain cortex and showed an advantage in treatment of traumatic brain edema. The level of calcium in the brain cortex was 16.78±4.98mmol/kg dry brain cortex and brain fluid content was 78.98±0.89 in the white matter.
出处
《第一军医大学学报》
CSCD
1992年第3期219-222,共4页
Journal of First Military Medical University
