摘要
实验选用急性间歇性可见光(荧光灯光源,光强度为18175±300Lux,光照周期为1小时光照:1小时暗适应,共3个周期)作为损伤光源。损伤后,大鼠视网膜组织内丙二醛(MDA)含量增高,视网膜组织结构受到破坏,血-视网膜外屏障受损。于光照前12小时及光照前即刻两次给大鼠注射山莨菪碱(10mg/kg)能够有效地抑制光损伤所致的MDA含量增高及保护视网膜的组织结构。
Acute intermittent visible fluorescent light was used as an experimental light source (18175±300lux, 1 hour dark: 1 hour light, 3 cycles). After light exposure, the myeloperoxidase activity (MDA) levels increased in rat retina, and the retinal structure and blood-retinal barrier were damaged. When 2 doses of anisodaminum (10 mg/Kg) were given 12 hours and just before light exposure, MDA levels lowered and the retinal structure was protected.
出处
《眼科》
CAS
1996年第1期44-47,共4页
Ophthalmology in China
关键词
山莨菪碱
视网膜损伤
药理学
Retina/injury
Radiation injury/prevention and control
Atropine/analogy and derivatives
Radiation-protective agents/pharmacology
