摘要
目的:评价雷公藤多甙预防冠脉内支架植入术后再狭窄的临床疗效。方法:75例冠脉内支架植入术成功的冠心病患者随机分为常规治疗组45例和常规治疗加雷公藤多甙组(简称雷公藤组)30例,疗程均为6个月。经冠状动脉造影(CAG)复查,静息99mTc-MIBI-SPECT心肌灌注断层显像,追踪观察患者有无心绞痛复发,评价雷公藤多甙对冠脉再狭窄的影响。结果:雷公藤组19例(回访率63.33％)、常规治疗组26例(回访率57.78％)复查CAG,雷公藤组净获得为(1.58±0.53)mm、净获得指数为55±23、管腔面积净获得为(3.07±0.52)mm2,均大于常规治疗组[分别为(1.30±0.64)mm、44±18、(2.41±0.38)mm2。,均P<0.05],同时病变狭窄百分比[(27.7±18.6)％]<常规治疗组[(37.3±21.7)％,P<0.05],雷公藤组再狭窄率为33.33％,常规治疗组再狭窄率为44.82％,两组比较差异无显著性(P>0.05);雷公藤组心肌灌注断层显像示心肌病变面积(17.18±6.25)％明显小于常规治疗组[(22.42±5.52)％,P<O.05],病变区和最大计数区放射性计数百分比[(56.51±22.37)％]明显高于常规治疗组[(50.28±20.71)％,P<O.05];雷公藤组心绞痛复发率(16.67％)低于常规治疗组(42.22％,P<0.05)。结论:雷公藤多甙对预防冠脉内支架植入术后再狭窄有一定作用。
Objective: To evaluate the clinical preventive effect of Tripterygium polyglycosides (TPG) in preventing restenosis after intracoronary stenting. Methods: Seventy-five coronary heart disease patients with successful intracoronary stenting were randomized into the control group (n =45) and the treated group (n - 30). Conventional treatment was given to both groups and TPG was given to the treated group additionally. The course of treatment was 6 months for them. Occurrence of restenosis was followed-up by coronary angiography and emission computerized tomography with 99m Tc-MIBI-SPECT for estimating the effect of TPG on restenosis. Results: The follow-up rate in the control group and the treated group was 57.78% (26/45) and 63. 33% (19/30) respectively. Coronary angiographic examination showed that comparing between treated group and control group, the net gain index (1. 58 ?0. 53 mm vs 1.30 ?0.64 mm), net gain index (55 ?23 vs 44 ?18), lesion area net gain (3. 07 ?0. 52 mm2 vs 2.41 ?.38 mm2) were higher in the treated group than those in the control group (all P<0.05), while the stenosis percent in the former was lower than that in the latter (27.7 ?8.6% vs 37.3 ?21.7% , P < 0.05) . The restenosis rate in the treated group was 33. 33% and that in the control group was 44. 82%, comparison between them showed no significant difference. Tomographic examination showed that the myocardial abnormal area in the treated group was 17. 18 ?6. 25%, significantly less than that in the control group (22. 42 ?5. 52%, P<0.05), while the emission count ratio of abnormal area and maximum count area in the former was higher than that in the latter (56. 51 ?22.37 % vs 50.28 ?20. 71 % , P < 0.05). Comparison of the angina recurrence rate between the two groups also showed significant difference (16.67% vs 42. 22 % , P < 0.05). Conclusion: TPG has definite effect in preventing restenosis after intracoronary stenting.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2002年第12期894-898,共5页
Chinese Journal of Integrated Traditional and Western Medicine
