摘要
３１只大鼠行胸主动脉内皮剥脱术，随机分为对照１０只，雷公藤多甙１０只和藻酸双酯钠组１１只，后两组于术前６天开始喂药。于术后１４天观察各组大鼠胸主动脉新生内膜面积，内膜与中膜面积比，新生内膜覆盖率，＾３Ｈ－ＴｄＲ参入量。证明雷公藤甙能显著抑制受损动脉内膜增生，而酸双酯钠则无此作用。
31 rat were divided randomly into control group (n=10),tripterygium wilfordii glycosides group (n = 10 9. 4 mg/kg per day),and poly saccharide sulphate group (n=11. 30 mg/per day). We made balloon endothelium denudation in thoracic aortae of the rats. The treatments with drugs began 6 days before balloon injury and continously until the animal were killed 14 day after balloon injury. The determinations for area of neointima, neointima /media, coverage of neointima and 3H-TdR incoperation of thoracic aortae suggested that tripterygium wilfordii glycosides can inhibit intimal proliferation of injuried aorta, whill poly saccharide sulphate shows no effect.
出处
《中国介入心脏病学杂志》
1996年第4期186-188,共3页
Chinese Journal of Interventional Cardiology
关键词
雷公藤多甙
藻酸双酯钠
血管内膜
增生
药理学
Intima Proliferation Tripterygium wilfordii glycosides Poly saccharide sulphate
