摘要
目的 :观察川芎嗪注射液治疗慢性肺心病急性发作期的临床疗效 ,客观评价川芎嗪注射液对慢性肺心病急性期患者血液动力学和血液流变学的影响。方法 :选取慢性肺心病急性发作期病例 30例 ,随机分为常规治疗组 (1 5例 )与川芎嗪治疗组 (1 5例 )。常规治疗组采用西医治疗 ,即抗感染、止咳化痰、解痉平喘、强心、利尿、持续低流量吸氧、保持呼吸道通畅和维持水、电解质平衡等治疗措施。川芎嗪治疗组在上述治疗的基础上加用川芎嗪注射液。两组治疗 1 0天为一个疗程。用ZK— 1 0C型计算机肺阻抗血流图检测仪及血液流变学检测仪检测两组患者用药前后的血液动力学及血液流变学某些参数的变化以及临床症状体征的变化 ,比较两种治疗措施的临床疗效。结果 :川芎嗪治疗组显效率和总有效率分别为 55 .33 %和93 .33 % ,均明显优于常规治疗组 (33 .33 %和 60 % ) ,两组临床总有效率经统计学处理有显著性差异 (X2 =4.65 ,P <0 .0 5) ;川芎嗪治疗组治疗后患者的Q -B/B -Y比值、Q -BI、肺动脉平均压等与常规治疗组比较均有明显降低 (P <0 .0 5～ 0 .0 1 ) ;B -YI、P2 -Y、Hs和α上升时间均有所增加 ;血液流变学多项指标除血沉、红细胞压积外 ,与常规治疗组比较均有显著性差异 (P <0 .0 5)。
ObjectiveTo study the clinical effect of Tetramethyl Pryaxine injection on chronic cor pulmonale in attack period so as to evaluate objectively the therapeutic effect of Tetramethyl Pryaxine injection on hemodynamic and hemorrheologic parameters of patients.Method:Thirty cases of cor pulmonale in attack period were divided into conventional treatment group of fifteen cases and Tetramethyl Pryaxine injection treatment group of fifteen cases at random.The conventional treatment group was treated with western medicine therapy,incliding anti-infection,ease cough,reduce phlegm,ease grasp,cardiotonic,diuretic,constant oxygen inhalation,keep respiratory tract from impeding,maintain balance of water and electrolyte metabolism etc;The tetramethyl Pryaxine injection treatment group was treated with Tetramethyl Pryaxine injection treatment on the basis of conventional treatment group therapy method,and 10days as one course.After the treatment,the clinical symptoms,physical examination,hemodynamic and hemorrheologic parameters of patients were studied and the clinical effects of the two methods were compared.Result:In Tetramethyl Pryaxine injection treatment group,the obvious effective rate and total effective rate were 55.33% and 93.33% respectively,and it was superior to the conventional treatment group(33.33%and 60%respectively).The difference of the total effective rate was obvious between two groups(x 2=4.65,P<0.05).After therapy the ratio in Q-B/B-Y,Q-B index and mean pulmonary artery pressure were decreased obviously(P<0.05～0.01,respectively),and the B-Y index,P 2-Y interval,Hs and α-rising time were increased in comparison with the conventional treatment group.At the same time,the hemorrheologic parameters were improved except erythrocyte sedimentation rate and hemotocrit,and it was a statistical significanece compard to the conventional treatment group.In controlling the clinical symptoms,physical examination,improving hemodynamic and hemorrheology etc,the Tetramethyl Pryaxine injection treatment group has more significant effect than the conventional treatment group(all P<0.05).
出处
《中医药学刊》
2002年第6期843-845,共3页
Study Journal of Traditional Chinese Medicine
