摘要
本研究为用益气活血复方组成的肺压宁和川芎嗪治疗４０例慢性肺心病患者的临床观察，和防治急性低氧性肺动脉高压的实验研究。结果表明：肺压宁和川芎嗪均能扩张肺血管，降低肺动脉压和肺血管阻力，增加心输出量，改善心功能和血液流变性，抑制低氧性肺血管收缩，且肺压宁的效果优于川芎嗪。
40 Patients with chronic cor pulmonale(CCP) were treated with Feiyaning(FYN),a Yiqi Huoxue compound prescription,and ligustrazine(LT) were reported.The results showed that FYN and LT could lower the pulmonary artery pressure(PAP) significantly;decrease the pulmonary vascular resistance(PVR) as well as the consumption of oxygen in cardiac muscle; increase cardiac output(CO);improve some indices in hemorrheology,while PaO 2 and SaO2 didn't change apparently.Moreover,lowering of FYN on PAP and PVR were superior to that of LT.The experimental studies showed that LT and injection of FYN could completely inhibit the hypoxia caused increase of PAP and PVR in rats;reduce the hypoxia caused pulmonary artery hypertension (PAH) and improve PVR of rats,as well as increase CO.The effects of FYN were superior to LT's. Although LT and FYN could decrease systemic arterial pressure to certain extent, they didn't induce systemic artery hypotension.It suggest that LT could reduce PAH definitely.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1994年第8期469-473,共5页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
川芎嗪
肺心病
肺性
高血压
缺氧
cor pulmonale,pulmonary hypertension, hypoxia,ligustrazine,Yiqi Huoxue
