摘要
微囊藻毒素是淡水湖泊蓝藻产生的一类肽类毒素 ,它的产生受到藻类的遗传和环境因素共同影响。微囊藻毒以肝脏为靶器官 ,通过多种作用引起肝细胞坏死 ,抑制蛋白磷酸酶 1(PP1)和蛋白磷酸酶 2A(PP2A)的活性 ,具有致癌性 ,是肿瘤促进剂。微囊藻及其毒素的污染已成为一个受人关注的公共卫生问题。由于微囊藻毒素污染的广泛性、持续性以及它所具有的热稳定性和水溶性 ,可能存在潜在的食品安全问题。本文综述了微囊藻及其毒素的污染、微囊藻毒素的产生原因和毒理学研究现状 ,预防的基本原则 。
In recent years, there has been an apparent increase in the occurrence of harmful algal blooms occurring in freshwater lake. Microcystin can be produced by the bloom-forming cyanobaterium microcystis aeruginosa. The amount of microcystin from blue-green algae has been affected by different factors of their hereditary and environmental factors. Microcystis and microcystin pollution in freshwater lake is receiving increasing attention around the world as a public health concern. Microcystins are potent hepatotoxin, probabable tumor promoters and inhibitor of protein phosphatases-1 and -2A(pp). Considering there are microcystins with universality and durative, as well as their stability and water-solubility in freshwater, they may be exist potential food safety to consumers. This review described conditions of cyanoteracterium microcystis aeruginosa and microcystins pollution, production mechanism of microcystins, toxicological actuality of microcystins and basic principle of prevent as well as some suggestions of farther studying.
出处
《卫生研究》
CAS
CSCD
北大核心
2002年第6期477-480,共4页
Journal of Hygiene Research
基金
卫生部科研基金资助项目 (No.98 1 0 67)
