摘要
本文应用组织学的方法,观察了吡喹酮引起的NIH小鼠体内细粒棘球蝴的变化。结果表明,在剂量为500mg/kg/d ,连续给药15及90天时,生发层变性及坏死的发生率依次分别为41.3％及36.5％和23.5％及70.7％,两组间坏死率的差别有高度显著性(P<0.001);原头节变性及死亡的发生率依次分别为37.9％及1O.3％和28.4%及65.4％,两组间死亡率的差别亦有高度显著性(P<0.001)。连续治疗30～90天,少数细粒棘球蚴的角质层出现不同程度的局部破裂及炎性细胞侵入,部分受损生发层的表面还有炎性细胞的粘附。
NIH mice, each infectred i.p. with 2000 protoscolices of E. granulosus for 1 year, were treated with praziquantel at a daily dose of 500 mg.kg-1 for 15 or 90d and then sacrificed at various intervals after termination of treatment for histological observation.The results were as follows:
1. The degeneration rate and necrosis rate of germinal layer on the 15th and 90th days were 41.3% and 36.5% as well as 23.5% and 70.75% respectively. No complete recovery of germinal layer was seen even six months after the cessation of the medication in 90-day group; 2. A few and many degenerated and dead protoscolices of E. granulosus were seen 15 and 90 days post medication, the rate of degeneration and death of protoscolex on day 15 and day 90 were 37.9% and 10.3% as well as 28.4% and 65.4% respectively. The difference of necrosis and dead rates both in germinal layer and protoscolex of E. granulosus in two groups was statistically significant; 3. In a few E. granulosus cyst, small vacuolations and focal ruptures of laminated layer were observed 30, 60 and 90 days after treatment, in some of them, the inflammatory cells invaded the damaged germinal layer and adhered to it.
The results suggest that the long-term therapy of praziquantel is more effective on E.
ranulosus cyst according to histopathological findings.
出处
《地方病通报》
1992年第3期1-4,共4页
Endemic Diseases Bulletin
基金
卫生部科学基金
关键词
吡喹酮
长程疗法
细粒棘球蚴
Praziquantel
Long term therapy
NIH mice
Echinococcus granulosus
Germinal layer
Protoscolex
Histology
