摘要
非结核分枝杆菌(nontuberculosis mycobacterium,NTM)引发的人类疾病日益增多,其病症范围从皮肤损伤到全身性疾病不等,且患者预后较差。此类细菌广泛存在于自然环境中,导致人类暴露于该菌的情况极为常见。但对非结核分枝杆菌的准确识别和鉴定以及对该病的诊断治疗仍是当前面临的主要挑战。非结核分枝杆菌病治疗过程复杂,需长期联合使用多种药物,不仅致使治疗成本较高,还常给患者带来不良反应。中医药作为中国的传统医学,在感染性疾病的治疗方面有着悠久的历史和丰富的经验,近年来,对中药的关注越来越多,同时研究资料显示,在治疗非结核分枝杆菌病方面中药具有一定的潜力,能够提高临床疗效,改善患者症状,减轻西药不良反应,逆转NTM耐药等。本文从NTM病的流行病学特征,耐药现状,抗生素治疗和中医在NTM病治疗方面的应用进行探讨,期望能为临床治疗提供更多的思路与方法,提升对该疾病的治疗水平。
Globally,human diseases caused by non-tuberculous mycobacteria(NTM)are increasingly prevalent,with clinical manifestations ranging from skin lesions to systemic diseases,and the prognosis of patients is relatively poor.These bacteria are widely distributed in natural environments,leading to extremely common exposure of humans to them.In view of the above characteristics,accurate identification and characterization of the NTM,as well as the formulation of appropriate subsequent treatment regimens,remain major challenges at present.The treatment of NTM diseases is complex and requires the long-term combined use of multiple drugs,which not only results in high treatment costs but also often causes adverse reactions in patients.Traditional Chinese Medicine(TCM),as traditional Chinese medicine,has a long history and rich experience in the treatment of infectious diseases.In recent years,growing attention has been paid to TCM,and research data have shown that TCM possesses certain potential in the treatment of NTM diseases.It can improve clinical efficacy,alleviate patients'symptoms,reduce adverse reactions of Western medicines,and reverse NTM drug resistance,etc.This article explores the epidemiological characteristics,current status of drug resistance,antibiotic treatment,and application of TCM in the treatment of NTM diseases,aiming to provide more insights and approaches for clinical treatment,improving the treatment level of this disease,and benefiting more patients.
作者
江丽娜
王春花
JIANG Lina;WANG Chunhua(Tianjin Center for Tuberculosis Control,Tianjin 300011,China)
出处
《中国热带医学》
北大核心
2026年第3期448-454,共7页
China Tropical Medicine
基金
天津卫生健康行业高层次人才选拔培养工程项目(TJSJMYXYC-D2-017)。
关键词
非结核分枝杆菌
抗生素
耐药性
中医药
Nontuberculous mycobacteria
antibiotic
drug resistance
traditional Chinese medicine
