摘要
儿童时期根除幽门螺杆菌对预防远期严重并发症(如萎缩性胃炎、消化性溃疡及胃癌)具有重要意义。然而,由于幽门螺杆菌耐药率上升及多重耐药菌的出现,当前广泛采用的经验性治疗面临着根除率下降、不良反应增加和治疗成本升高的困境。相比之下,个体化治疗通过抗生素敏感性试验与质子泵抑制剂代谢关键基因多态性检测,针对性选择有效抗生素并且优化抑酸方案,有效提高了根除率。该文综述了当前治疗策略与耐药现状,强调个体化治疗在提高儿童幽门螺杆菌根除率和应对耐药挑战中的重要意义与应用前景。
Eradication of Helicobacter pylori during childhood holds strategic significance for preventing long-term severe complications,such as atrophic gastritis,peptic ulcers,and gastric cancer.However,current empiric treatment faces substantial challenges due to escalating antibiotic resistance and the emergence of multidrug-resistant strains,which result in declining eradication rates,increased adverse events,and higher treatment costs.In contrast,personalized therapy,which is guided by antimicrobial susceptibility testing and detection of key gene polymorphism in proton pump inhibitor metabolism,allows for selecting effective antibiotics and optimizing acid suppression regimens,thereby achieving higher eradication rates.This article reviews current treatment strategies and resistance patterns,highlighting the significance and future potential of personalized therapy in improving eradication rates and combating resistance in Helicobacter pylori infection in children.
作者
孙常溪
邓朝晖
Sun Changxi;Deng Zhaohui(Department of Gastroenterology,Shanghai Children′s Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China)
出处
《国际儿科学杂志》
2026年第1期6-10,共5页
International Journal of Pediatrics
基金
上海市浦东新区卫生健康委员会2024年度卫生科技项目(PW2024D-02)。
关键词
儿童
幽门螺杆菌
抗生素耐药
经验性治疗
个体化治疗
Child
Helicobacter pylori
Antibiotic resistance
Empiric treatment
Personalized therapy
